参苓白术散加味治疗肺癌骨转移的临床研究  

Clinical Study on Analgesic Effect of Shen-ling-bai-zhu Powder on Pain in Bone Metastasis of Lung Cancer

作　　者：丰哲[1] 练克俭[2] 林宗汉[3] 李书振[3] 陈涛[3] 程琦[3] 

机构地区：[1]福建中医药大学 [2]解放军175医院,福建漳州363020 [3]广西中医药大学附属瑞康医院,广西南宁530011

出　　处：《中医药导报》2013年第10期1-3,6,共4页Guiding Journal of Traditional Chinese Medicine and Pharmacy

基　　金：广西壮族自治区科学技术厅青年基金(0728081)

摘　　要：目的:观察参苓白术散加味治疗肺癌骨转移的疗效。方法:将128例本病患者随机分为治疗组和对照组各64例。治疗组采用参苓白术散加味治疗,对照组采用帕米膦酸二钠、塞来西布结合支持疗法治疗。观察比较两组患者镇痛效果、生存质量、生存期。结果:治疗组脱落5例,对照组脱落8例;综合疗效总有效率治疗组为66.1%,对照组为44.6%,治疗组优于对照组(P<0.05);止痛效果总有效率治疗组为71.2%,对照组为42.9%,治疗组优于对照组,差异有统计学意义(P<0.05);生活质量的改善对照组提高率为28.6%,治疗组提高率为59.3%,治疗组优于对照组,差异有统计学意义(P<0.05);两组治疗前后体重变化、两组生存期比较,差异均无统计学意义(P>0.05);治疗组治疗后白细胞计数优于对照组(P<0.05);并能显著改善恶心呕吐、便秘(P<0.01)。结论:参苓白术散加味能较好地缓解肺癌骨转移疼痛,提高生存质量,而且未见明显毒副作用。Objective： To observe the analgesic effect on pain by Shen-ling-bai-zhu powder in bone metastasis of lung cancer. Methods： 128 patients were randomly divided into treatment and control groups, 64 cases in each group. Patients were treated with Shen-ling-bai-zhu powder, and pamidronate disodium and celecoxib, combined with support therapy in control group. The analgesic effect, quality of life, survival rate was observed. Results： The displacement was 5 and 8 cases respec- tively in treatment and control group; The total comprehensive effective rate was 66.1% and 44.6% respectively in treatment and control group, the effect of treatment group was significantly better than the control group （P〈0.05）; The comprehensive ef- fective rate of analgesic was 71.2% and 42.9% respectively in treatment and control group, the effect of treatment group was significantly better than the control group （P〈0.05）; The improvement of quality of life rate was 59.3% and 28.6% respectively in treatment and control group, the increase rate in treatment group wass better than the control group （P〈0.05）; The weight changes and survival between two groups showed no significant difference; The leucocyte count in the treatment group was bet- ter than the control group （P〈0.05）; The symptoms of nausea and vomitting and constipation relieved in treatment group （P〈 0.05）.Conclusion： Shen-ling-bai-zhu powder can relieve the pain of bone metastasis of lung cancer and improve the quality of life, and there is no obvious side effect.

关 键 词：疼痛 肺癌骨转移 参苓白术散加味 生活质量 帕米膦酸二钠 

分 类 号：R273[医药卫生—中西医结合]