甲亢宁治疗甲状腺功能亢进症合并肝损伤80例临床研究  

A Clinical Observation of Jiakangning on Hyperthyroidism Patients with Liver Injury with 80 Cases

作　　者：蔡欣蕊[1] 钱卫斌[2] 姜群群[1] 李群英[1] 钱秋海[3] 

机构地区：[1]山东中医药大学 [2]日本鸟取大学医学部 [3]山东中医药大学附属医院,山东济南250011

出　　处：《中医药导报》2013年第10期10-12,共3页Guiding Journal of Traditional Chinese Medicine and Pharmacy

基　　金：山东省中医药科技发展计划项目(2007-037)

摘　　要：目的:观察甲亢宁治疗甲亢合并肝损伤的临床疗效。方法:将160例甲亢合并肝损伤患者随机分为治疗组和对照组各80例。治疗组予甲亢宁及基础治疗,对照组予天晴甘平及基础治疗,治疗12周后观察两组患者的FT3、FT4、TSH、基础代谢率、ALT、AST、ALP、γ-GT、TBiL。结果:治疗12周后,两组患者的TSH水平均升高,FT3、FT4、BMR均降低,差异有统计学意义(P<0.01);两组治疗后比较,治疗组FT3、FT4、BMR均低于对照组(P<0.01),TSH高于对照组(P<0.01)。治疗12周后,治疗组患者的ALT、AST、ALP、γ-GT、TBIL水平均降低(P<0.01或P<0.05),对照组治疗后ALT、AST、ALP水平均降低(P<0.01);两组治疗后比较,治疗组ALT、AST、ALP、γ-GT、TBIL均低于对照组,差异有统计学意义(P<0.01或P<0.05)。结论:应用甲亢宁可明显纠正甲状腺功能亢进症合并肝损患者的甲状腺功能及基础代谢率,同时能降低相关肝功能指标,减轻肝脏损害。Objective： To observe the effect of Jiakangning on hyperthyroidism patients with hepatic injury. Methods： 160 hyperthyroidism patients with hepatic injury were randomly divided into treatment and control groups. Patients were treated with Jiakangning in treatment group and Diammonium Glycyrrhizinate in control group. The FT3, FT4, TSH, basal metabolic rate, ALT, AST, ALP, γ--GT and TBiL were observed after 12 weeks. Results： TSH levels were elevated and the FT3, FT4, BMR were lowered in treatment and control groups, with statistically significant difference （P〈0.01）. After treatment, the Fr3, FT4 and BMR in treatment group were lower than that of the control group, TSH higher than that of the control group （P〈 0.01）. ALT, AST, ALP, γ-GT and TBIL levels decreased in treatment group （P〈0.01 or P〈0.05）. ALT, AST and ALP levels were lower in control group after treatment （P〈0.01）. After treatment, ALT, AST, ALP,γ-GT, TBIL in treatment group were lower than that in control group and the difference was statistically significant （P〈O.01 or P〈0.05）. Conclusion： Jiakangning can balance the Thyroid function and make the liver function better.

关 键 词：甲亢合并肝损伤 甲状腺功能 肝功能 基础代谢率 甲亢宁 

分 类 号：R259[医药卫生—中西医结合]