齐拉西酮与氯丙嗪对精神分裂症患者认知功能的影响  

Effect of ziprasidone and chlorpromazine on cognitive function in patients with schizophrenia

作　　者：胡怡[1] 张轶杰[1] 刘琼[1] 

机构地区：[1]云南省精神病医院,昆明650224

出　　处：《临床精神医学杂志》2013年第5期327-329,共3页Journal of Clinical Psychiatry

摘　　要：目的:探讨齐拉西酮与氯丙嗪对精神分裂症患者认知功能的影响。方法:80例精神分裂症患者随机分为研究组和对照组,并分别给予齐拉西酮或氯丙嗪治疗8周。分别于治疗前和治疗后应用威斯康星卡片分类测验、韦氏记忆测验和河内塔测验评定两组患者的认知功能。结果:治疗8周后,研究组威斯康星卡片分类测验、韦氏记忆测验及河内塔测验各项成绩明显优于治疗前和对照组(P均<0.05)。结论:与氯丙嗪比较,齐拉西酮能明显改善精神分裂症患者的认知功能。Objective ：To explore the effect of ziprasidone and chlorpromazine on cognitive function in pa- tients with schizophrenia. Method ： Eighty schizophrenia patients were randomly divided into the research group and control group, each of which accepted the treatment with ziprasidone or chlorpromazine respectively for 8 weeks. Before and after treatment, the cognitive function were evaluated by Wisconsin card sorting test （WCST）, Wechsler memory scale （WMS） and tower of Hanoi （TOH） in the two groups. Results：After 8 weeks of treatment,all the results of WSCT,WMS and TOH in research group were significantly better than be- fore treatment and control group （ all P 〈 0.05 ）. Conclusion： Compared with chlorpromazine, ziprasidone can remarkably improve the cognitive function in patients with schizophrenia.

关 键 词：齐拉西酮 氯丙嗪 精神分裂症 认知功能 

分 类 号：R749.3[医药卫生—神经病学与精神病学]