聚果多酚抗自由基及抗氧化作用研究  

Experimental study of JuGuoDuoFen on the Anti-radical and antioxidant function

作　　者：王雅婷[1] 孙静[2] 董瓅瑾[3] 赵艳威[2] 

机构地区：[1]武警后勤学院物理教研室,天津300309 [2]武警后勤学院药理教研室,天津300309 [3]武警后勤学院科研部,天津300309

出　　处：《武警后勤学院学报（医学版）》2013年第9期812-813,817,共3页Journal of Logistics University of PAP（Medical Sciences）

摘　　要：【目的】观察聚果多酚的抗自由基作用。【方法】将40只老龄大鼠随机分为3个剂量聚果多酚组(25、50和100 mg/kg)、VE组(35 mg/kg)、老龄对照组,每日灌胃分别给与相应药物或生理盐水,连续给药35 d,测定心肌脂褐素(lipofuscin,LF)、血浆超氧化物歧化酶(superoxide dismutase,SOD)、脂质过氧化物(malodndaldegyde,MDA)、谷胱甘肽过氧化物酶(glutathione peroxidase,GSH-Px)活性。【结果】给予聚果多酚大鼠血浆SOD和GSH-Px活力显著提高(P<0.01),而MDA和LF含量则明显下降(P<0.05)。【结论】聚果多酚能抑制自由基损伤,防止脂质过氧化,具有明显延缓衰老作用。[Objective] To study the Anti-radical and antioxidant function of compound JuGuoDuoFen in rats. [ Methods] 40 old rats were randomly divided into 5 groups： 3 compound JuGuoDuoFen groups（25, 50, 100 mg/kg）, VE group, control group. All group rats were treated with drugs or NS through oral gavage. The activities of superoxide dismutase（SOD） and glutathione peroxidase（GSI-I-Px） in blood, the contents of malodndaldegyde（MDA） in plasma, lipofuscin（LF）in heart were determined by biochemical methods. [ Results] compound JuGuoDuoFen could significantly improve the activities of SOD and GSH-Px in blood（P 〈 0.01 ）, decrease the contents of the MDA and LF （P 〈 0.05）. [Conclusions] compound JuGuoDuoFen has obvious anti-aging effects, which may result from its antioxidation enzymes and the prevention of ]tipid peroxidation in tissues.

关 键 词：聚果多酚 抗衰老 超氧化物歧化酶 脂质过氧化物 谷胱甘肽过氧化物酶 脂褐素 

分 类 号：R96[医药卫生—药理学]