Unanticipated role of apelin： regulation of miRNA generation  

作　　者：Deguan Lv Qixuan Lu Jiangang Cao Linxi Chen 

机构地区：[1]Institute of Pharmacy and Pharmacology, University of South China, Hengyang 421001, China

出　　处：《Acta Biochimica et Biophysica Sinica》2013年第10期896-898,共3页生物化学与生物物理学报（英文版）

摘　　要：Recently, a paper by Kim et al. [1] in Nature Medicine magazine in January, 2013 showed that apelin （also known as APLN） inhibits fibroblast growth factor 2 （FGF2） and FGF receptor 1 （FGFR1） expression to ameliorate pulmonary hypertension by regulating the expression of miR-424 and miR-503. This study revealed the molecular mechanism of apelin in inhibiting the process of pulmonary arterial hyper- tension （PAH） and discovered the role ofapelin in regulating miRNA generation for the first time.Recently, a paper by Kim et al. [1] in Nature Medicine magazine in January, 2013 showed that apelin （also known as APLN） inhibits fibroblast growth factor 2 （FGF2） and FGF receptor 1 （FGFR1） expression to ameliorate pulmonary hypertension by regulating the expression of miR-424 and miR-503. This study revealed the molecular mechanism of apelin in inhibiting the process of pulmonary arterial hyper- tension （PAH） and discovered the role ofapelin in regulating miRNA generation for the first time.

分 类 号：Q516[生物学—生物化学] Q522