臌胀片在HBeAg阳性慢性乙型病毒性肝炎治疗中的减毒增效作用  

Attenuated and Synergistic Effect of Meteorism Tablets in Treatment of HBeAg-positive Chronic Hepatitis B

作　　者：王会丽[1] 高天曙 杨小平[1] 赵玉瑶[1] 

机构地区：[1]河南省中医药研究院附属医院,河南郑州450004 [2]河南中医学院第二附属医院,河南郑州450004

出　　处：《中国中医药信息杂志》2013年第11期8-10,共3页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：河南省中医药继承与创新专项(072103810804)

摘　　要：目的观察臌胀片在乙肝e抗原(HBeAg)阳性慢性乙型病毒性肝炎治疗中的减毒增效作用。方法将80例HBeAg阳性慢性乙型肝炎患者随机分为治疗组(臌胀片联合替比夫定)和对照组(替比夫定),均治疗1年,观察治疗前后2组患者丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、乙肝病毒-DNA(HBV-DNA)阴转率、HBeAg阴转率、HBeAg/HBeAb血清学转换率、血清肌酸激酶(CK)水平及安全性。结果治疗48周后,治疗组ALT、AST、HBV DNA阴转率、HBeAg阴转率及HBeAg/HBeAb血清学转换率均优于对照组(P<0.05)。2组患者均有CK升高,其中治疗组13例(32.5%),对照组24例(60.0%),2组比较差异有统计学意义(P<0.05)。结论臌胀片与替比夫定联合用药后,其减毒增效作用显著。Objective To observe the attenuated and synergistic effect of meteorism tablets in treating HBeAg-positive chronic hepatitis B patients. Methods Eighty patients of HBeAg-positive chronic hepatitis B were randomly divided into treatment group （meteorisrn tablets combined with telbivudine） and control group （telbivudine）, and treated for one year. The changes of alanine aminotransferase （ALT） and aspa_r^te aminotransferase （AST）, the negative rate of HBV-DNA, the negative rate of HBeAg, HBeAg/HbeAb serological conversion rate, creatine kinase （CK） before and after treatment, and safety were observed. Results After treatment, biochemical response, virological response and HBeAg serological response was more significant in the treatment group than that in the control group （P 〈0.05）. The percetage of patients with elevated CK in the treatment group was significantly lower than that in the control group （32.5% vs 60%, P〈0.05）. Conclusion Meteorism tablets combined with telbivudine has attenuated and synergistic effect in treating HBeAg-positive chronic hepatitis B patients.

关 键 词：慢性乙型病毒性肝炎 乙肝E抗原 臌胀片 替比夫定 减毒增效 

分 类 号：R259.126.2[医药卫生—中西医结合]