超微七味白术散体外抑菌作用研究  

Inhibiting Effect of Ultra-micro Powder Qiweibaizhusan on Bacteria in Vitro

作　　者：蒋婕[1] 郭抗萧[1] 龙玲[1] 李丹丹[1] 谭周进[1] 袁振仪[1] 

机构地区：[1]湖南中医药大学,湖南长沙410208

出　　处：《中国中医药信息杂志》2013年第11期28-30,共3页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：国家自然科学基金(81173214);第一届湖南省大学生研究性学习和创新性实验计划项目(185)

摘　　要：目的观察七味白术散单味药及超微七味白术散复方及其传统复方的抑菌效果。方法采用抑菌圈测量法研究七味白术散各单味药及复方水煎液对大肠杆菌、金黄色葡萄球菌、产气杆菌、绿脓杆菌、沙门氏菌、酿酒酵母和假丝酵母的抑菌效果及最低抑菌浓度。结果人参对除金黄色葡萄球菌和沙门氏菌外的其他5种菌都有明显的抑菌效果;甘草抑菌作用最强,仅对绿脓杆菌无抑菌效果;藿香叶对金黄色葡萄球菌和产气杆菌有明显的抑菌效果;白茯苓对大肠杆菌、金黄色葡萄球菌、产气杆菌和绿脓杆菌均有抑菌效果;木香和炒白术仅对产气杆菌有抑菌效果;葛根对7种供试菌均无抑菌作用。七味白术散复方的传统汤药和超微汤药均对金黄色葡萄球菌、产气杆菌和沙门氏菌抑菌作用明显,且超微汤药对各菌的最低抑菌浓度均小于传统汤药。结论七味白术散中主要的抑菌组分为人参和甘草,且超微中药的抑菌效果较传统中药好。Objective To observe the bacteriostatic effect of single herbs, traditional complex prescription and ultra-micro powder of Qiweibaizhusan. Methods The inhibiting zone and MIC of single herb and compound of Qiweibaizhusan on Escherichia coli, Staphylococcus aureus, Eubacterium aerofaciens, Pseudomonas aeruglnosa, Salmonella sp, Saceharomyces cerevisiaes and Candida glabrata were measured by filter paper method. Results The growth of the tested bacteria and yeast except Staphylococcus aureus and Salmonella sp were inhibited by ginseng. The antibacterial effect of hcoriee was the best, and only Pseudomonas aeruglnosa＇s growth was not inhibited by hcorice. The growth of Staphylococcus aureus and Eubacterium aerofaciens were inhibited by Agastache rugosa. The growth of Eseherichia coli, Staphylococcus aureus, Eubacterium aerofaciens and Pseudomonas aeruginosa were inhibited by Poria cocos. Only Eubacterium aerofaciens＇s growth was inhibited by Radix aucklandiae and fried Atractylodes macroeephala. The growth of all the bacteria and yeast were not inhibited by Radix puerariae. The growth of Staphylococcus aureus, Eubacterium aerofaciens and Salmonella sp were inhibited by the traditional decoction and ultra-micro powder of complex prescription of Qiweibalzhusan, and all the MIC of ultra-micro powder were smaller than the traditional decoction. Conclusion The main antibacterial component of Qiweibaizhusan was ginseng and licorice. The inhibiting effect of ultra-micro powder on bacteria was better than traditional decoction of Qiweibaizhusan in vitro.

关 键 词：七味白术散 超微中药 单味药 复方 抑菌作用 

分 类 号：R285.5[医药卫生—中药学]