兰瑞肽的制备  

Preparation of Lanreotide

作　　者：杨桂英[1,2] 东圆珍[2] 朱裕辉[2] 许激扬[1] 冯军[2] 

机构地区：[1]中国药科大学生命科学与技术学院,江苏南京210009 [2]中国医药工业研究总院上海医药工业研究院,创新药物与制药工艺国家重点实验室,上海200040

出　　处：《中国医药工业杂志》2013年第10期961-965,共5页Chinese Journal of Pharmaceuticals

基　　金：国家"重大新药创制"科技重大专项(2012ZX9301002003-004)

摘　　要：以Rink Amide MBHA树脂为载体、Fmoc保护的氨基酸为原料,按照兰瑞肽的氨基酸序列合成兰瑞肽粗肽;经环化后分离纯化,得到纯度为99%以上的兰瑞肽产品,总收率达17.7%;并讨论了影响兰瑞肽制备的因素,对工艺条件进行了优化。The crude peptide of lanreotide was successfully synthesized according to its amino acid sequence by using Rink Amide MBHA resin as a solid support and Fmoc-amino acids as raw materials. After cyclization, the crude peptide was isolated and purified. The purity of lanreotide was more than 99 % and the total yield was 17.7 %. Finally, the impact factors on the process was discussed.

关 键 词：兰瑞肽 固相合成 生长抑素 工艺条件 

分 类 号：R977.9[医药卫生—药品]