盐酸利多卡因柔性纳米脂质体对小鼠皮肤的渗透性  

Permeability of Lidocaine Hydrochloride Ultradeformable Nanoliposomes in Mouse Skin

作　　者：申玉坤[1,2] 周晋阳[1] 申玉璞[2] 潘一峰[2] 

机构地区：[1]长治医学院,山西长治046000 [2]中南大学湘雅医学院卫生部纳米生物技术重点实验室,湖南长沙410008

出　　处：《中国医药工业杂志》2013年第10期1001-1004,共4页Chinese Journal of Pharmaceuticals

基　　金：国家863计划资助项目(2007AA021809)

摘　　要：采用改良Franz扩散池考察盐酸利多卡因(1)柔性纳米脂质体和普通纳米脂质体对小鼠离体皮肤的累积渗透情况,结果前者9 h累积渗透量高于后者。将上述两种剂型分别非封闭性应用于小鼠皮肤进行在体鼠皮渗透性试验。结果表明,1柔性纳米脂质体组和1普通纳米脂质体组小鼠皮肤中的t max分别为5和60 min,且前者c max是后者的1.2倍。普通纳米脂质体组小鼠血浆内未检出药物,柔性纳米脂质体组在0.5和1 h时检出微量药物,但浓度低于有效浓度。The in vitro permeabilities of lidocaine hydrochloride （1） from ultradeformable nanoliposomes and common nanoliposomes through the excised mouse skin were determined by modified Franz diffusion cell. The results showed that the accumulative amount of 1 at 9 h from the ultradeformable nanoliposomes was higher. The above preparations were non-occlusively applied onto mouse skin in vivo to investigate the penetration of product. The results in skin showed that tmax values of ultradeformable nanoliposomes and common nanoliposomes were 5 and 60 min, and the Cm,x of the former was 1.2 times higher than that of the latter. The drug was not detected in plasma in common nanoliposomes group, while trace drug was detected in plasma collected at 0.5 and 1 h in ultradeformable nanoliposomes group. But the detected concentrations were lower than the effective concentration.

关 键 词：盐酸利多卡因 柔性纳米脂质体 普通纳米脂质体 渗透性 

分 类 号：R944.9[医药卫生—药剂学]