异丙酚-芬太尼静脉全麻下人工流产术后恶心呕吐危险因素分析  

Risk factors for postoperative nausea and vomiting following induced abortion under propofol-fentanyl total intravenous anesthesia

作　　者：黎尚荣[1] 王韧[1] 沈宁[1] 

机构地区：[1]中山大学附属第三医院麻醉科,广州市510630

出　　处：《实用医学杂志》2013年第20期3309-3311,共3页The Journal of Practical Medicine

基　　金：广东省科技计划项目(编号:2010B080701084)

摘　　要：目的:观察异丙酚-芬太尼静脉全麻下人工流产术后恶心呕吐(PONV)的发生情况,分析其相关的危险因素。方法:采用成组设计的病例-对照研究方法。141例接受人工流产术的患者,术前填写相关因素登记表,术中观察并记录麻醉时间、手术时间、麻醉药用量,麻醉苏醒期及术后24 h追踪记录PONV发生情况。PONV定义为苏醒期至术后24 h内发生恶心、干呕或呕吐。对各种因素进行单因素及多因素分析,多因素分析采用Logistic(Forward法)逐步回归。结果:54例患者发生了PONV,发病率为38.3%。单因素分析显示麻醉时间、手术时间、丙泊酚用量是PONV的危险因素(均P<0.05),Logistic逐步回归分析并未能进一步筛选出独立的危险因素。结论:异丙酚-芬太尼静脉全麻下人工流产术后PONV的发病率为38.3%,麻醉时间、手术时间、丙泊酚用量可能是PONV发生的危险因素。Objective To investigate the incidence of postoperative nausea and vomiting （PONV） following induced abortion under propofol-fentanyl total intravenous anesthesia （TIVA） and to analyze its related risk factors. Methods Case-control study was used on 141 patients undergoing induced abortion. A questionnaire was completed before operation, and the time of anesthesia, operative time and anesthetic dose were recorded. The incidences of PONV were observed in anesthesia recovery room and 24 h after the operation. The definition of PONV included nausea, retching and vomiting within 24 h after the operation. Single factor analysis and Logistic stepwise regression analysis were done to analysis the risk factors for PONV. Results 54 patients （38.3%） suffered from PONV. Single factor analysis showed that the risk factors included the time of anesthesia, operation time and propofol dosage （both P 〈 0.05）. However, the Logistic stepwise regression analysis could not screen out the independent predictor for PONV. Conclusion The incidence of PONV following induced abortion under propofol-fentanyl TIVA was 38.3%. The time of anesthesia, operation time and propofol dosage may be the risk factors for PONV.

关 键 词：人工流产术 全凭静脉麻醉 术后恶心呕吐 危险因素 

分 类 号：R614[医药卫生—麻醉学]