推拿对一次性力竭运动DOMS大鼠模型血清IL-6的影响  

The Effect of Tuina to Serum IL-6 of DOMS Rat Model After One Time Eccentric Exercise

作　　者：吴云川[1] 马荣连[2] 王家祥[3] 顾一煌[1] 李怡[1] 孙永[1] 蒋晓玲[3] 孙飙[3] 金宏柱[1] 

机构地区：[1]南京中医药大学第二临床医学院,江苏南京210023 [2]江苏省省级机关医院,江苏南京210046 [3]南京体育学院,江苏南京210046

出　　处：《时珍国医国药》2013年第10期2562-2564,共3页Lishizhen Medicine and Materia Medica Research

基　　金：江苏省教育厅高校自然科学基金基础研究资助项目(No.07KJB360088)

摘　　要：目的观察推拿对DOMS大鼠模型血清IL-6的影响。方法将130只6周雄性SD大鼠按照随机原则分为安静组(A)、运动对照组(B)、运动前推拿组(C)、运动后推拿组(D)。实验中B1、C48、D48组因大鼠死亡各脱落1例,共计脱落3例,完成实验大鼠共计127只。除空白安静组外,大鼠均进行力竭游泳训练,负重为大鼠体重的3%。由专人运用捏法和捻法施于大鼠的两侧下肢,观察血清IL-6的变化。结果运动后1 h大鼠血清IL-6处于较高水平(P<0.01),然后下降至安静组水平,24 h逐渐上升至48 h出现显著升高的变化(P<0.01)。与运动对照组比较,运动前推拿组在1 h组有显著差异,血清IL-6数值降低(P<0.01);运动后推拿组在1,48 h组有差异性,血清IL-6数值降低(P<0.01)。运动后推拿组在48 h血清IL-6显著低于运动前推拿组(P<0.01)。结论推拿对DOMS大鼠模型血清IL-6异常有干预效应,运动后推拿对血清IL-6干预优于运动前推拿。Objective To explore the influence of the serum IL -6 about Tuina treating the DOMS rat model. Methods 130 healthy and clean male SD rats of six -week old were randomly divided into 4 groups including normal control group（A） , exercise control group（B） , pre -exercise Tuina group（C） and post -exercise Tuina group （D）. Group B, C and D were randomly divid- ed into lh, 12h, 24h and 48h groups. Each group consists of 10 rats. 3 rats died in B1 ,C48 and D48 groups, so 3 cases were lost, totally 127 rats finished experiment. Except the group A, the other groups i＇ats all trained by exhausting swimming with carry- ing a subject of 3% body weight. Tuina manipulation：Two lower limbs of rat were treated by pinching manipulation and holding - twisting manipulation. Observe index was senun IL - 6. Results The level of serum IL - 6 was high in 1 h after exercise （ P 〈 0. 01 ）, then dropped down to the level of group A, but rose again in 24h to 48h gradually（P 〈0.01 ）. In comparison with the group B, the level of serum IL -6 of group C reduced in 1 h （P 〈 0.01 ） , and the level of serum IL -6 of group D reduced in 1 h and 48h （ P 〈 0.01 ） , the level of serum IL - 6 of group D was lower than group C （ P 〈 0.01 ）. Conclusion Tuina can intervene on serum IL - 6 of DOMS Rat Model. Intervention of post - exercise Tuina is better than pre - exercise Tuina. Key words

关 键 词：推拿 大鼠 白细胞合素-6 

分 类 号：R2-03[医药卫生—中医学]