中等多棘神经元的多房室模型分析  

Multi-Compartment Model Analysis of the Medium Spiny Neuron

作　　者：江小芳[1] 刘深泉[1] 张煦晨[1] 

机构地区：[1]华南理工大学理学院数学系,广州510640

出　　处：《生物物理学报》2013年第7期527-542,共16页Acta Biophysica Sinica

基　　金：国家自然科学基金项目(10872069)~~

摘　　要：中等多棘神经元是纹状体的主神经元,它与中枢神经系统的很多疾病紧密相关。作者基于生物系统的中等多棘神经元模型,首先通过对比中等多棘神经元对直流、交流和方波三种电流刺激模式的响应,得到丰富的发放模式,特别研究了外界交流刺激的变化对中等多棘神经元放电节律的影响;其次,通过改变不同离子(钠、钾和钙)通道的最大电导系数或通透性来分析其对中等多棘神经元活动特性的影响;最后,通过移除部分树突的方法模拟部分树突死亡与退化对中等多棘神经元的影响,在相同的外界刺激条件下,通过对比得出5种缺失情况与完整神经元动作电位的差异。通过模拟结果可以看到,所有的内源与外源因素对于中等多棘神经元的放电节律均有重要影响。Medium spiny neurons are the principal neurons in striatum, which are closely related to many diseases of the central nervous system. Based on medium spiny neuron model of biological systems, the authors obtained various firing patterns by comparing the responses of the medium spiny neuron under direct current, alternating current and square wave firstly, and the results showed that the change of alternating current had a huge influence on the firing rhythm of this neuron. Then, this study researched the impact of three different ions conductance or permeability （sodium, potassium, calcium） on the firing properties of medium spiny neuron. Finally, by removing part of dendrites which simulated the death and degradation of them, the difference between the firing pattern of the healthy neuron and the incomplete neuron had been gained. According to the simulated results above, both the endogenic factor and extrinsic factor have effect on the firing rhythm of the medium spiny neuron.

关 键 词：中等多棘神经元 放电节律 最大电导系数 振幅 

分 类 号：Q42[生物学—神经生物学]