针灸对原发性骨质疏松症影响的实验和临床研究  

Experimental and clinical studies of effects of acupuncture and moxibustion on primary osteoporosis

作　　者：刘献祥[1] 吴明霞[2] 吴炳煌[1] 章志安[1] 钱松涛[1] 李俐[2] 林薇[1] 郑良朴[1] 林久茂[1] 

机构地区：[1]福建中医学院,福建福州350003 [2]福建省第二人民医院

出　　处：《中国骨伤》2000年第9期519-521,共3页China Journal of Orthopaedics and Traumatology

基　　金：福建省自然科学基金! (No .C970 4 9)

摘　　要：探讨针刺和艾灸治疗原发性骨质疏松症的疗效。方法　动物实验采用 12月龄雌性大鼠 6 5只 ,随机分为正常对照组、手术对照组、模型组、雌二醇组、针刺组和艾灸组 ;采用摘除双侧卵巢法建立骨质疏松症的模型 ,造模 3个月后治疗 3个月 ,进行骨代谢生化指标、性激素水平、骨小梁等观测针刺和艾灸的疗效。临床研究选择骨质疏松女性患者 30例 ,随机分为针刺组和艾灸组各 15例 ,治疗前和治疗 3个月检查腰椎骨密度。结果　经针刺、艾灸或雌二醇治疗后 ,S AKP、U Ca/Cr、U HOP/Cr较模型组分别有所下降 ;S E2 、S BGP较模型组升高 (p <0 0 5～ 0 0 1) ;骨小梁与髓腔的宽度比值 ,针刺、艾灸和雌二醇较模型组接近正常。 30例骨质疏松患者骨密度治疗前和治疗后 ,针刺和艾灸组分别提高1 95 %和 2 43%。结论　针刺、艾灸和雌二醇三者的作用无明显差异 ,针灸是防治骨质疏松症的有效方法之一。Objective To explore experimental and clinical results of acupuncture and moxibustion for the treatment of primary osteoporosis.Methods 65 female S.D.rats aged 12 months were randomly divided into 6 groups:normal control group,Sham operated group,models group,estradiol group,acupuncture group,moxibustion group.Osteoporosis models were produced by bilateral ovariectomy.The treatment was carried out in models of 3 months and the treatment period lasted for 3 months.The effect of acupuncture and moxibustion was determined by the measurement of the biochemical indexes of bone metabolism,the level of sex hormone and bone morphometry.In the clinical tests,30 female cases of osteoporosis were randomly divided into two groups:acupuncture group and moxibustion group.Bone density of lumbar vertebral was determined at 3 months before treatment and after treatment.[HT5”H]Results [HT5”SS]After the treatment,serum AKP,Urine Ca/Cr,Urine HOP/Cr in the estradiol group,acupuncture group and moxibustion group were significantly lower than those in the model group;serum estradiol(E 2),BGP in the estradiol group,acupuncture group and moxibustion group were significantly higher than those in the model group(p<0 05～0 01);the width ratio of bone trabecula to marrow cavity in the estradiol group,acupuncture group and moxibustion group was close to normal standard than that in the model group.Before and after treatment,the bone density of 30 cases in the acupuncture group and moxibustion group raised 1 95% and 2 43% respectively.[HT5”H]Conclusion [HT5”SS]There were no significant differents among the therapy of acupuncture,moxibustion and serum estradio.Acupuncture and moxibustion was effective way for the treatment and prevention of osteoporosis.

关 键 词：骨质疏松 骨密度 针刺疗法 治疗 

分 类 号：R274.91[医药卫生—中西医结合] R246.2[医药卫生—中医骨伤科学]