纳米孔分析化学  

Nanopore Analytical Chemistry

作　　者：阴笑弘[1] 朱新宇[1] 顾菁[1] 张欣[1] 朱志伟[1] 邵元华[1] 

机构地区：[1]北京大学化学与分子工程学院分析化学研究所北京分子科学国家实验室,北京100871

出　　处：《分析化学》2013年第5期633-640,共8页Chinese Journal of Analytical Chemistry

基　　金：国家自然科学基金(No.21075004);教育部创新团队资助项目

摘　　要：源于自然界,服务于人类社会的纳米尺度装置包括生物及人工制备的纳米孔与纳米通道等。基于这些纳米尺度装置的分析化学简称纳米孔分析化学。本文对纳米孔分析化学的发展,特别是近年来在DNA测序、蛋白质分析的进展进行了综述,对于纳米孔分析化学发展的历史、基本分类、原理和应用作了介绍与展望。There is a plenty of biological nano-scale devices in nature, such as ion channels and protein pores, which inspired people to design and fabricate biomimetic systems （solid-state, hybrid nanopores and nano-channels） for analytical and sensing applications. Nanopore Analytical Chemistry designed based on these nano-devices are important for biosensors, nanofluidic devices, molecular filtration, synthetic biology, detection of single molecules and DNA sequence. In this paper, the history, classification, fundamental, applications and respects of nanopore analytical chemistry, especially recent advances of nanopore applications in DNA sequence and detection of proteins have been reviewed.

关 键 词：纳米孔 纳米通道 纳米孔分析化学 单分子检测 DNA测序 综述 

分 类 号：TB383.1[一般工业技术—材料科学与工程] O651[理学—分析化学]