疾病标记物分子印迹技术在分离传感分析中的应用  

Applications of Disease Makers Molecularly Imprinting Technology in Separation and Sensing

作　　者：王莹[1] 黄春芳[1] 梁汝萍[1] 邱建丁[1] 

机构地区：[1]南昌大学化学系,南昌330031

出　　处：《分析化学》2013年第5期787-794,共8页Chinese Journal of Analytical Chemistry

基　　金：国家自然科学基金(Nos.21065006;21265012);教育部新世纪优秀人才支持计划(No.NCET-11-1002)项目资助

摘　　要：疾病标记物分子印迹聚合物以疾病标记物为模板分子,可实现低浓度和基底复杂的疾病标记物的高效分离和富集。以疾病标记物分子印迹聚合物为敏感元件构建的传感器,可用于对威胁人类健康的高发病率和高死亡率疾病进行筛查和诊断。本文介绍了分子印迹技术的原理和方法,重点介绍了疾病标记物分子印迹中常用的印迹方法、印迹材料、以及疾病标记物分子印迹聚合物在疾病标记物分离及传感中的应用。Molecularly imprinting polymers （MIPs） based on molecularly imprinting technology （MIT） can serve as crude mimics of native receptors. In recent years, as MIPs exhibit special recognition and selective ability toward targets, they have caused extensive concern in this field. Disease markers MIPs make separation and enrichment for disease markers of low concentration and complex substrate possible. Sensors that make use of disease markers MIPs as sensitive components can screen and diagnosis of diseases which seriously threat to people＇s health with high incidence and mortality. This review is meant to focus on overviews of MIT, with a particular focus on the imprinting methods, imprinting materials and applications of disease makers MIPs in separation and sensing.

关 键 词：分子印迹 疾病标记物 分离 传感 评述 

分 类 号：O631.3[理学—高分子化学]