不同糖耐量状态血清脂联素水平的比较及其相关因素的研究  

Study on the adiponectin levels in different glucose intolerance statuses and their related factors

作　　者：张秀英[1] 周翔海[1] 罗樱樱[1] 韩学尧[1] 任倩[1] 张春芳[2] 阴津华[3] 黎明[3] 纪立农[1] 

机构地区：[1]北京大学人民医院内分泌科,北京大学糖尿病中心,100044 [2]北京大学人民医院临床流行病学中心,100044 [3]北京协和医院内分泌科

出　　处：《中国糖尿病杂志》2013年第10期896-899,共4页Chinese Journal of Diabetes

基　　金：国家高技术研究发展计划863项目(2006AA02A409)

摘　　要：目的比较不同糖耐量状态下的血清APN水平及其相关影响因素。方法选取糖耐量正常(NGT组)者403名、糖调节受损(IGR组)者454例及新诊断T2DM患者(T2DM)366例。检测各组空腹状态下APN、FPG、FIns及血脂水平。结果不同糖耐量状态下,女性血清APN水平高于男性(P<0.01)。T2DM、IGR组FPG、FIns、TG及LDL-C水平高于NGT组,血清APN和HDL-C水平下降(P<0.05)。与IGR组比较,T2DM组TG水平升高,HDL-C水平下降,血清APN水平较IGR组高(P均<0.05),两组FIns及LDL-C水平比较差异无统计学意义。性别、BMI、FIns、TG及HDL-C水平是血清APN的独立相关因素(P<0.05)。结论血清APN水平在糖尿病前期阶段呈下降趋势,且与肥胖、血脂异常和IR有关,血清APN水平的测定有助于T2DM早期预测和诊断。Objective To compare the APN levels in different glucose intolerance statuses and study on their related factors. Methods Those people with normal glucose tolerance （NGT, n：403）, those subjects with impaired glucose regulation （IGR, n： 454）, and those patients newly diagnosed type 2 diabetes （T2DM, n=366） were involved in this study. The levels of APN, FPG, Fins, and blood lipid in a fasting condition of all participants were measured for observation. Results The fasting serum APN level in women was significantly higher than in men in different glucose tolerance statuses （P〈0.01）. Compared with the NGT group, the levels of FPG, Fins, TG, and LDL-C were significantly higher in newly diagnosed T2DM and IGR patients, whereas their HDL-C and APN levels were significantly decreased （all P〈0.05）. Compared with the IGT group, the level of TG in the newly diagnosed T2DM patients was increased, the level of HDL C was decreased, and the level of APN was higher （all P〈0.05）. There were no significant differences in Fins and LDL-C levels between participants in the T2DM and IGR groups. The gender and the BMI, Fins, TG, and HDL-C levels were all independent relevant factors of circulating APN concentrations （P〈0.05）. Conclusion The serum ANP level shows a downward trend early in the pre-diabetes stage. It is associated with obesity, dyslipidemia, and insulin resistance. Determination of serum APN levels might contribute to the early prediction and diagnosis of T2DM.

关 键 词：糖尿病 2型 糖调节受损 脂联素 胰岛素抵抗 

分 类 号：R587.1[医药卫生—内分泌]