白藜芦醇对2型糖尿病大鼠血糖及抗氧化酶活力的影响  

Effect of resveratrol on the blood glucose level and antioxidase activity in diabetic rats

作　　者：朱孝娟[1] 宋柏捷[1] 杨艳辉[1] 

机构地区：[1]黑龙江省哈尔滨医科大学附属第二医院临床营养科,150086

出　　处：《中国糖尿病杂志》2013年第10期947-949,共3页Chinese Journal of Diabetes

摘　　要：目的观察白藜芦醇(Res)对T2DM大鼠血糖及抗氧化酶活力的影响。方法采用随机数字表法将50只健康Wistar大鼠分为正常对照组(NC,10只),给予基础饲料喂养。余40只使用STZ腹腔注射制备T2DM模型,后将大鼠随机分为模型(T2DM)组、Res低剂量(50mg/kg,L)组及高剂量(100mg/kg,H)组,每组10只。予高糖高脂饲料喂养8周后测定FPG、FIns、HbAl c、血清超氧化物歧化酶(SOD)活性、谷胱甘肽过氧化物酶(GSH-Px)活力和丙二醛(MDA)含量。结果与T2DM组相比,H组和L组FPG、FIns、HbAl c下降,血清SOD活性、GSH-Px活力上升,MDA含量降低,差异有统计学意义(P<0.05)。结论Res可改善糖尿病大鼠的抗氧化能力,抑制脂质过氧化,降低血糖。Objective To observe the effect of resveratrol on the blood glucose level and antioxidase activity in diabetes rats. Methods Of the 50 healthy Wistar rats, 10 were taken randomly as normal control group, given basic diet, and the others were intraperitoneally injected with low dose of streptozotocin （STZ） to induce T2DM models, which were later randomized into T2DM group, resveratrol low dose（50 mg/kg,L） and high dose （100 mg/kg, H） groups, with 10 rats in each. After feeding high fatty and high sugar diet for 8 weeks, the FPG, Fins, and HbAlc, superoxide dismutase （SOD）, glutathione peroxidases （GSH-Px）, and malondialdehyde （MDA） of the rat models were detected respectively for analysis. Results Compared with the T2DM group, the levels of FPG, Fins, and HbA1 c decreased, the activities of SOD and GSH-px increased, and the MDA content lowered in the resveratrol low dose and high dose groups, with a significant statistical difference （P 〈0.05）. Conclusion Resveratrol improves the antioxidative ability, inhibits lipid peroxidation, and decreases the blood glucose level of diabetic rats.

关 键 词：白藜芦醇 糖尿病 2型 血糖 抗氧化 大鼠 

分 类 号：R587.1[医药卫生—内分泌]