山东省健康人群风疹抗体水平分析  

Analysis on Serum Levels of Rubella Antibodies among Healthy People in Shandong Province

作　　者：王常银[1] 许青[1] 宋立志[1] 房学强[1] 李炜修[1] 徐爱强[1] 

机构地区：[1]山东省疾病预防控制中心山东省预防摔制传染病重点实验室,济南250014

出　　处：《中国疫苗和免疫》2013年第4期341-344,共4页Chinese Journal of Vaccines and Immunization

基　　金：国家科学技术艾滋病和病毒性肝炎等重大传染病防治重大专项传染病监测技术平台项目(编号:2009ZX1004-201和2009ZX1004-202);山东省医药卫生科学研究项目(编号:2009HD014)

摘　　要：目的评价山东省健康人群风疹抗体水平。方法2009年和2010年共选取山东省12个设区的市，各市按照分层随机原则选取〈2岁～≥40岁共8个年龄组的健康人群作为观察对象，并采集血清标本，用酶联免疫吸附试验单孔定量方法检测风疹免疫球蛋白（Immunoglobulin，Ig）G，并进行统计分析。结果2009、2010年12个市共检测健康人群血清标本4001份，风疹抗体阳性率为83．13％、抗体几何平均浓度（Geometric Mean Concentration，GMC）为40．42国际单位／毫升（IU／ml）。2010年明显高于2009年。不同地区和不同年龄组人群风疹抗体阳性率及GMC差异均有统计学意义（X2=81．254，P〈0．01；F=8．55，P〈0．05；X2=44．273，P〈0．01；F=3．68，P〈0．05），不同性别人群差异均无统计学意义（X2=0．100，P〉0．05；F=28．63，P〉0．05）。≤10岁儿童风疹抗体阳性率较低，其中〈2岁、5～7岁儿童阳性率〈80％。抗体阳性率随年龄增长升高趋势明显，但抗体GMC总体呈降低趋势，尤以≥20岁成人更为明显。结论加强儿童麻疹-风疹联合减毒活疫苗（Measlesand Rubella Combined Attenuated Live Vaccine，MR）的常规免疫接种，控制风疹流行；同时应关注育龄期妇女MR的预防接种，预防先天性风疹综合征。Objective To evaluate the immunity of healthy population to rubella virus in Shandong province. Methods All objects aged from 〈2 to ≥ 40 years old were divided into 8 age groups randomly from 12 cities in Shandong province and their serum samples were collected in 2009 and 2010. The immunoglobulin （Ig）G antibodies were detected by single hole quantitive enzyme-linked immunosorbent assay and the results were analyzed. Results 4001 samples were tested in this study. Serum positive rate was 83.13% and geometry mean concentration （GMC） was 40.42 international unit （IU）/ml. Serum positivity and GMC were different in different areas（ X2=81.254,P〈0.01 ;F=8.55, P〈0.05）and different age groups （X2=44.273, P〈0.01 ;F=3.68, P〈0.05）. The results in the year of 2010 were higher than the year in 2009. However, there were no differences according to the gender （X2=0.100, P〉0.05 ;F=28.63, P〉0.05）. The serum positive rate was low in group ≤ 10 years old. It was lower than 80% in the group〈2 years old and 5-7 years old. The serum positivity rose with the age, but the GMC decreased, especially in adults group ≥ 20 years old. Conclusion It is very important to strengthen the routine immunization of the rubella vaccine to control the epidemic of rubella virus. Meanwhile, the immunity of the women who is going to be pregnant should be payed attention to prevent the congenital rubella syndrome.

关 键 词：健康人群 风疹 风疹免疫球蛋白G 

分 类 号：R511.2[医药卫生—内科学]