盐酸小檗碱淀粉微球的制备研究  

Study on the preparation of berberine hydrochloride cross-linked starch microspheres

作　　者：杨黎燕[1] 杨礼铭 杨礼诚 余丽丽[1] 

机构地区：[1]西安医学院药学院,西安710021 [2]西安高新唐南中学高中部,西安710075

出　　处：《化工新型材料》2013年第10期42-44,共3页New Chemical Materials

基　　金：国家自然科学基金资助项目(81302706);陕西省教育厅科研资助项目(2013JK0759);西安医学院科研计划项目(12FZ04)

摘　　要：采用包埋法制备盐酸小檗碱淀粉包合物微球,通过均匀试验设计优化其制备工艺。采用电镜、红外、X衍射对包合物进行表征。结果表明,影响盐酸小檗碱淀粉包合物微球制备因素的大小依次为:投药比>交联剂的量>乳化剂的量>反应时间。盐酸小檗碱与淀粉微球投料比为0.05,交联剂用量0.9g,乳化剂用量0.9g,反应时间2h。盐酸小檗碱淀粉微球制备方法可行。The berberine hydrochloride cross-linked starch microspheres（BH-CSMs）were prepared by encapsulation,and the preparation process was optimized through uniform design. BH-CSMs was characterized by SEM, IR and XRD. Results showed that influence factors of preparation was dosage ratio 〉 crosslinking doses 〉reaction time） emulsified doses in oder. The best technological conditions were that the quantity of soluble starch, Berberine Hydrochloride, crosslinking doses, emulsified doses was 4g,0. 02 g, 0. 9g, 0.9g respectively and the reacting time was 2h. The preparation method was feasible.

关 键 词：淀粉微球 盐酸小檗碱 包埋载药 均匀设计 

分 类 号：TQ460.1[化学工程—制药化工]