味连须肠溶微丸包衣处方的筛选  

Study on the coating formula of Fibrous Root Coptidis enteric-coated pellets

作　　者：代姝[1] 周晓燕[1] 丁国蓉[1] 刘汉儒[1] 

机构地区：[1]西南大学药学院,重庆400715

出　　处：《中兽医医药杂志》2013年第4期9-12,共4页Journal of Traditional Chinese Veterinary Medicine

基　　金：石柱黄连规范化种植基地及其SOP优化升级研究(2011BAI13B02-1)

摘　　要：以挤出滚圆法制备味连须微丸为载药丸芯,以丙烯酸树脂Ⅱ和Ⅲ为包衣材料,利用多功能造粒包衣机对丸芯进行包衣。以味连须微丸体外释放度为指标,通过单因素试验考察丙烯酸树脂Ⅱ和Ⅲ的比例、增塑剂用量、抗静电剂用量和包衣增重,探讨不同包衣处方对药物释放度的影响。结果表明,Ⅱ、Ⅲ号丙烯酸树脂比例为2∶1,增塑剂用量为聚合物用量的20%,滑石粉为聚合物用量的0.3%,包衣增重10%为优化处方。Fibrous Root Coptidis pellets were prepared by extrusion-spheronization method and enteric-coated using multifunctional rolling machine.Though determining the release rate of berberine in Fibrous Root Coptidis enteric-coated pellets,the proportion of acrylic resin Ⅱ and Ⅲ,content of plasticizer-diethyl phthalate,content of antistatic agent-talc powder,and the coating weight gain were investigated.The optimized formulation were 2∶1 of acrylic resinⅡand Ⅲ,20% of diethyl phthalate and 0.3% of talc powder in total polymers,and 10% increase of coating weight.

关 键 词：味连须 肠溶微丸 丙烯酸树脂 

分 类 号：S853.73[农业科学—临床兽医学]