胰复生降血糖作用的实验研究  

Hypoglycemic Effects of Yifusheng on Experimental Animals with Hyperglycemia

作　　者：卢盛华[1] 张华 马剑峰[1] 曹伟[1] 王菊英[1] 刘萍[1] 

机构地区：[1]山东医科大学基础医学院药理教研室,济南250012 [2]山东省新泰市糖尿病研究所,山东新泰271200

出　　处：《中药新药与临床药理》2000年第5期284-285,共2页Traditional Chinese Drug Research and Clinical Pharmacology

摘　　要：观察胰复生对实验性高血糖动物的血糖、C肽、胰岛素和胰腺组织的影响。结果胰复生高、低剂量组均能显著降低四氧嘧啶诱发的糖尿病大鼠的血糖 (P <0 .0 1 ) ,升高血清中C肽和胰岛素水平 (P分别小于0 .0 5和 0 .0 1 ) ,减轻四氧嘧啶造成的胰腺组织损害。另外 ,胰复生能对抗肾上腺素诱发的家兔血糖升高。Hypoglycemic effects of Yifusheng on hyperglycemia animals induced by alloxan or adrenaline were studied.The result showed that Yifusheng in the dosage of 0.25 g/kg and 0.125 g/kg could significantly decrease the content of plasma blood sugar(P< 0.01 ),elevate the concentrations of C_peptide and insullin(P< 0.05 and P< 0.01 respectively) and reduce pancreatic injury in alloxan diabetes rats.In addition,Yifusheng could also counteract the increase of blood sugar in hyperglycemia rabbits induced by adrenaline.

关 键 词：@胰复生/药理学 糖尿病/中药疗法 胰岛素/药物作用 动物疾病模型 

分 类 号：R285.5[医药卫生—中药学] R259.871[医药卫生—中医学]