愈疡消痛方防治消化性溃疡复发  

Clinical Research of Prevention and Treatment of Peptic Ulcer Recurrence by Yuyang Xiaotong Prescrition

作　　者：陈江[1] 朱雄雄[1] 龚诚[1] 

机构地区：[1]苏州市中医医院,江苏苏州215009

出　　处：《中国实验方剂学杂志》2013年第21期294-297,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：江苏省中医药管理局项目(2010S012)

摘　　要：目的:观察愈疡消痛方防治消化性溃疡(PU)复发的临床疗效。方法:将96例PU患者随机按数字法分为观察组和对照组各48例。对照组口服雷尼替丁片,0.15 g/次,2次/d,奥美拉唑肠溶胶囊,40 mg/次,1次/d。若幽门螺杆菌(HP)阳性加用阿莫西林胶囊,0.5 g/次,3次/d,甲硝唑片,0.4 g/次,2次/d,观察组在对照组治疗的基础上加服愈疡消痛方,1剂/d,疗程4周。疗程结束后对照组采用雷尼替丁片维持治疗4周,观察组以愈疡消痛方维持治疗4周。进行治疗前后胃镜检测评价内镜下再生黏膜成熟度及组织学再生黏膜成熟度,采用免疫组化检测溃疡黏膜解痉多肽(SP)表达,观察临床症状变化情况,进行1年随访观察复发情况。结果:观察组胃镜疗效总有效率97.9%优于对照组的85.4%(P<0.05);观察组内镜下再生黏膜成熟度及组织学再生黏膜成熟度评价均优于对照组(P<0.01);观察组中医证候疗效总有效率100%优于对照组的79.1%(P<0.01);治疗后观察组胃痛、胃胀、食少纳呆、便溏不爽、嗳气、泛酸等症状评分低于对照组(P<0.01);观察组治疗后SP阳性表达较对照组明显增强(P<0.01);观察组复发率26.8%,低于对照组的60.0%(P<0.01)。结论:愈疡消痛方能明显减轻临床症状,提高PU愈合质量,降低复发率,近期、远期疗效均显著,其作用机制可能与增加SP表达有关。Objective： The purpose is to observe the clinical curative effect of this method in prevent recurrence of peptic ulcer （PU）. Method ： Ninety-six cases of PU patients were randomly divided into observation group （48 cases） and control group （48 cases）. The patients in the control group took omeprazole enteric capsules by oral, 20 mg/time, 2 times/day. If the HP of patients is positive, they took conventional trigeminy anti HP treatment. The patients in the observation group took, 1 dose/day. After the treatment, the patients in control group took omeprazole enteric capsules, 20 mg/time, 1 time/day, treatment course 4 weeks. While the observation group taking the Yuyang Xiaotong prescription during the 4 weeks. Gastroscope inspection was operated before and after the treatment to evaluate endoscopic mucosal maturity and histological regenerative mucosal maturity. By using immunohistoehemical method to detect the express of ulcer mucous membrane spasmolysis peptide （SP） to observe the changes of clinical symptoms, taking 1 year follow-up visiting to observe the recurrence situations. Result： The total effective rate of gastroscope inspection of the observation group was 97.9% , higher than 85.4% of control group （ P 〈 0.05 ）. The evolutions of endoscopic mucosal maturity and histological regenerative mucosal maturity in the observation group were superior to control group （P 〈 0.01 ）. The total effective rate of syndromes curative effect in the observation group was superior to that in the control group, with the rate 100% and 79.1% （P 〈 0.01）. After the treatment, the symptom score of stomach pain, bloating, eating less and stay, loose stool, belching, pantothenic acid and other symptoms was lower than the control group （P 〈 0.01 ）. The SP positive expression in the observation group was obviously increased （P 〈0.01 ）. The recurrence rate of observation group was 26.8% , lower than 60.0% of the control group （P 〈 0.01 ）. Conclusion： This method can signifi

关 键 词：消化性溃疡 愈疡消痛方 溃疡愈合质量 复发 溃疡黏膜解痉多肽 

分 类 号：R287[医药卫生—中药学]