自拟肠神方预防奥沙利铂慢性周围神经毒性临床观察  

Self-designed Changshen Prescription In Prevention from Peripheral Neurotoxicity Caused by Oxaliplation

作　　者：景晶[1] 徐国暑[1] 孙大兴[1] 

机构地区：[1]浙江省立同德医院,杭州310012

出　　处：《浙江中西医结合杂志》2013年第10期790-793,共4页Zhejiang Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的:观察自拟肠神方预防奥沙利铂慢性周围神经毒性的临床疗效。方法:选取病理明确,接受姑息性化疗(mFOLFOX6)的晚期结肠癌患者64例,随机分为治疗组42例,化疗联合肠神方内服外洗;对照组22例,化疗联合钙镁合剂治疗。疗程结束后评估周围神经毒性和疗效,并检测周围感觉神经传导速度和动作电位波幅。结果:10个周期化疗后,两组各级周围神经毒性发生率差异有统计学意义(P<0.05),且治疗组感觉神经传导速度和动作电位波幅的下降程度明显小于对照组(P<0.01)。两组肿瘤治疗效果无明显差异(P>0.05)。结论:肠神方内服外洗可以有效预防奥沙利铂引起的慢性周围神经毒性,对周围感觉神经功能有一定的保护作用,并且不影响化疗效果。Objective：To observe the therapeutic effect of self-designed Changshen prescription in the treatment of peripheral neurotoxicity caused by oxaliplation. Methods：Sixty-four patients with colon cancer at the end stage confirmed by pathology were randomly divided into control（22 patients） and Changshen（42 patients） groups. All pa- tients received palliative chemotherapy with mFOLFOX6R. Patients in the Changshen group was administered Changshen prescription orally and externally in addition and patients in the control group were given plus Ca/Mg infusion. Nerve toxicity and therapeutic effect was evaluated and peripheral sensory nerve conduction velocity（SCV） and action potential（SNAP） were tested in both groups after the full treatment. Results：After 10 cycles of chemother- apy,the patient in the Changshen group had an incidence of 85.3% of neurotoxicity,significantly lower than that of the control group（94.4%,P〈O.05）,and they also had a smaller reduction in SCV and SNAP（P〈0.OI）. The thera- peutic effect did not differ between the two groups（P〉0.05）. Conclusion：Applying Changshen prescription both o- rally and externally can effectively prevent patients from chronic peripheral neurotoxicity caused by oxaliplation and have protective effect on sensory nerve function,with the same anti-tumor effect as Ca/Mg infusion has.

关 键 词：慢性周围神经毒性 奥沙利铂 自拟肠神方 

分 类 号：R273[医药卫生—中西医结合]