大动物心衰模型研究进展  

Research progress on large animal models of heart failure

作　　者：徐创业[1,2] 蔺嫦燕[1,2] 

机构地区：[1]首都医科大学附属北京安贞医院,北京100029 [2]北京市心肺血管疾病研究所,北京100029

出　　处：《北京生物医学工程》2013年第5期536-540,共5页Beijing Biomedical Engineering

基　　金：国家863计划(2012AA041605);首都卫生发展科研专项(首发2011-1005-02);北京市自然科学基金(3112011)资助

摘　　要：心衰是一种复杂的临床综合征,严重威胁着人类生命健康。小动物心脏的病生理和解剖结构与人类存在较大差距,其心衰模型难以满足研究心衰发病机理和干预治疗的需求,因此,在病理生理学、结构功能和解剖方面更接近人类的大动物心衰模型成为研究热点。通过查阅近几年文献,本文综述了容量负荷过载型、压力负荷过载型、药源性、快速起搏型、心肌梗死型、分子基因型等大动物心衰模型的建立方法及应用评价,为各种诱因的心衰提供相应模型,增强研究的针对性。Heart failure （HF） is a kind of complex clinical syndrome and a severe threat to human life and health. Small animal models cannot meet the research needs for pathogenesis and therapeutic intervention of HF because of the inevitable differences in physiopathology and anatomical structures. Therefore, large animal models of HF have become imperative because they are closer to human in structure and function, physiopathology and anatomy. Upon review of literature in recent years,this paper summarizes the establishment methods and application evaluation of different kinds of large animal models of HF, such as volume overload, pressure overload, drug-induced,ventricular rapid pacing, myocardial infarction and molecular genetics,in order to promote pertinency of HF research.

关 键 词：心衰 动物模型 心肌梗死 

分 类 号：R318[医药卫生—生物医学工程]