依达拉奉治疗急性重型颅脑损伤的疗效探讨  

Clinical effect of Edaravone on acute severe traumatic brain injury

作　　者：刘滨[1] 杨涛[1] 王林[1] 王森[1] 刘帅[1] 

机构地区：[1]解放军第148医院神经外科,山东淄博255300

出　　处：《临床军医杂志》2013年第10期1020-1021,共2页Clinical Journal of Medical Officers

摘　　要：目的探讨依达拉奉对急性重型颅脑损伤的临床疗效。方法将50例急性重型颅脑损伤患者(GCS≤8分)采用随机数字表法随机分为两组:治疗组25例(依达拉奉+常规治疗)和对照组25例(常规治疗)。观察治疗后脑水肿的程度、治疗前后GCS评分、伤后3个月GOS评估情况。结果两组患者治疗10 d后,脑水肿程度均有所减轻,治疗组更明显;治疗组GCS评分显著高于对照组;治疗后3个月治疗组GOS预后分级显著高于对照组(P均<0.05)。结论早期应用依达拉奉对治疗急性重型脑损伤有较好的疗效。Objective To evaluate the clinical effect of Edaravone on acute severe traumatic brain injury （TBI）. Methods Fifty patients of acute severe TBI （GCS≤8） were divided into two groups by random number table, i.e. trial group （n = 25 ） treated with Edaravone and conventional treatment, control group （ n = 25 ） treated with conventional treatment. Observation included cere- bral edema after treatment, GCS before and after treatment, GOS assessment 3 months later after injury. Results Brain edema was reduced in both the two groups after l0 days＇ treatment, and the effect was more obvious in the trial group; GCS was higher in the trial group than in the control group ; GOS prognostic classification of the trial group was better than that of the control group 3 months later after treatment （ P 〈 0.05 ）. Conclusion It is suggested that the early application of Edaravone is therapeutically ef-fective on acute severe TBI.

关 键 词：依达拉奉 急性重型颅脑损伤 治疗 

分 类 号：R651.15[医药卫生—外科学]