临床病原菌的变迁及耐药性分析  

Distribution and drug resistance of clinical pathogenic bacteria

作　　者：郭健莲[1,2] 江先海[1,2] 肖斌龙 李强[3] 

机构地区：[1]中国人民解放军第一七五医院 [2]厦门大学附属东南医院检验科,福建漳州363000 [3]南方医科大学病理生理学教研室,广东广州510515

出　　处：《国际检验医学杂志》2013年第19期2514-2515,共2页International Journal of Laboratory Medicine

基　　金：广东省医学科研基金项目(B2011177)

摘　　要：目的通过分析2007~2011年临床病原菌的变迁及药敏情况,指导临床合理使用抗菌药物。方法 Walk Away 40SI细菌分析仪对细菌进行鉴定和药敏分析。结果 31 223份中标本共分离出病原菌86种9 850株,检出率为31.5%;7种主要病原菌中肺炎克雷伯菌居首位,其余依次为真菌、大肠埃希氏菌、铜绿假单胞菌、鲍曼不动杆菌、金黄色葡萄球菌和阴沟肠杆菌;铜绿假单胞菌对阿米卡星（8.9%）、庆大霉素（12.0%）和妥布霉素（9.1%）有较好的敏感性,鲍曼不动杆菌对替卡西林/克拉维酸钾和亚胺培南耐药性较低,对其他抗菌药物均呈现不同程度的耐药。肠杆菌科的大肠埃希氏菌和肺炎克雷伯菌对亚胺培南和哌拉西林/他唑巴坦的耐药性较低。结论细菌的多重耐药性在临床分离菌株中非常普遍,对临床抗感染治疗构成了严重的威胁,加强院内感染监测和采取有效的预防和控制措施具有十分重要的意义。Objective To study the distribution and drug resistance of bacteria isolated from clinical.Methods The bacterium were identified and antibiotic sensitivity tests were done by walk away 40SI microbe analytic instrument.Results There were 86 kinds in 9 850pathogenic bactrias isolated from 31 233samples（31.5%）.The most of 7main bacterias was K.pneumoniae,following were Fungi,E.coil,P.aeruginosa,A.baumannii,S.aureus and E.cloacae,P.aeruginosa had high sensitivity to amikacin（8.9%）,gentamicin（12.0%）and tobranmycin（9.1%）,A.baumannii had low drug resistance to ticarcillin-clavulanic acid and imipenem,K.pneumoniae and E.coil had resistance to imipenem and piperacilin-tazobactam.Conclusion Multiple drug-resistant are common in clinical isolated bacteria,which seriously threaten to clinical therapy,so strengthening monitoring of hospital infection and taking effective preventive and control measures are important.

关 键 词：病原菌 微生物敏感性试验 抗药性 微生物 

分 类 号：R446.5[医药卫生—诊断学]