血浆B型尿钠肽水平在心力衰竭诊断中的价值  

The value of plasma B-type natriuretic peptide in congestive heart failure diagnosis

作　　者：王海滨[1] 石新慧[1] 

机构地区：[1]中国人民解放军总医院第一附属医院检验科,北京100048

出　　处：《国际检验医学杂志》2013年第19期2544-2545,共2页International Journal of Laboratory Medicine

摘　　要：目的探讨慢性心力衰竭(心衰)患者血浆B型钠尿肽(BNP)水平变化及其临床意义。方法采用免疫化学发光分析法,测定63例住院心力衰竭患者血浆B型尿钠肽(BNP)水平(心衰组)和30例健康成人(对照组)血清BNP浓度,并按照纽约心脏病协会(NYHA)分级,比较不同NYHA级别BNP水平差异。结果 (1)心衰组BNP水平(868.5±302.8)pg/mL,明显高于对照组[(101.4±32.8)pg/mL](P<0.01)。(2)NYHA分级Ⅱ级患者BNP水平为(629.37±224.56)pg/mL,NYHA分级Ⅲ级患者BNP水平为(853.39±302.43)pg/mL,NYHA分级Ⅳ级患者BNP水平为(1 378.62±433.25)pg/mL,3组间两两比较差异有统计学意义(P<0.01)。结论 BNP水平随着心衰患者严重程度的加重而增加,对心衰患者的诊断、病情评估、预后判断具有重要临床意义。Objective To discover the changes of the chronic heart failure patients′plasma B type natriuretic peptide（BNP）and find its clinical significance.Methods BNP levels of 60chronic heart failure patients and 30healthy adults were measured by immunoassay chemiluminescent technique.60chronic heart failure patients were classified by NYHA and compared the differences of the levels of BNP.Results（1）the heart failure patients′BNP level was（868.5±302.8）pg/mL,obviously higher than the healthy people[（101.4±32.8）pg/mL]（P＆lt;0.01）.（2）,the levels of BNP were（629.37±224.56）pg/mL in chronic heart failure patients with gardiac functionⅡ,（853.39±302.43）pg/mL in chronic heart failure patients with cardiac functionⅢ,（1 378.62±433.25）pg/mL in chronic heart failure patients with cardiac functionⅣ.There was a remarkable difference（P＆lt;0.01）.Conclusion The level of BNP is obviously increased with the cardiac function aggravation,which has important significance for chronic heart failure diagnosis,disease assessment and prognosis judgment.

关 键 词：利钠肽 脑 心力衰竭 化学发光测定法 

分 类 号：R541.6[医药卫生—心血管疾病]