估计肾小球滤过率公式在健康中青年人群中的应用调查  

The application of five eGFR equations in healthy young and middle-aged population in Hu Nan province

作　　者：杨佳锦[1] 黄猛[1] 杨静静[1] 穆萨[1] 唐爱国[1] 

机构地区：[1]中南大学湘雅二医院检验科,湖南长沙410011

出　　处：《国际检验医学杂志》2013年第19期2550-2552,共3页International Journal of Laboratory Medicine

摘　　要：目的对5个eGFR公式在健康中青年人群的适用性进行调查,并建立本地区的eGFR参考区间。方法用5种不同eGFR公式分别计算本地区年龄为18~59岁健康体检者（n=1 074）的eGFR,并按性别和年龄进行统计分析。根据各公式计算出的eGFR的分布情况选出合适的公式,应用线性回归分析和Bland-Altman分析法比较入选公式计算结果的相关性和一致性。以最适公式的结果建立不同性别和年龄组的95%参考区间。结果简化MDRD、CKD-EPI和EPI-Asia公式能较正确的反映我省健康中青年人群的eGFR,三者有较好的相关性和一致性。男、女性eGFR比较差异有统计学意义（P〈0.01）。eGFR与年龄呈负相关（r2=0.651,P〈0.01）。EPI-Asia为最适公式,据此建立我省健康中青年男女不同年龄段的eGFR参考区间（单位：mL/min·1.73m2）。男性：（18~29）岁（107.0~151.7）,（30~39）岁（92.7~128.5）,（40~49）岁（94.5~123.1）,（51~59）岁（88.3~115.2）;女性：（18~29）岁（120.6~162.5）,（30~39）岁（113.9~139.0）,（40~49）岁（95.5~127.8）,（50~59）岁（90.9~113.2）。结论本次调查结果可靠,为eGFR公式的准确使用提供了参考。Objective To investigate five eGFR equations applicability in healthy young and middle-aged population of Hunan Province and establish the eGFR reference intervals.Methods The eGFR of the healthy subjects aged from 18to 59year-old（n= 1 074）were calculated by different five equations,then we analyzed the results for different gender and age groups.Appropriate eGFR equations were selected according to the distribution of the results,the linear regression analysis and Bland-Altman analysis were applied to compare correlation and consistency of the selected eGFR equation.Optimal equation was used to establish 95% of the eGFR reference intervals in different gender and age groups.Results The simplified MDRD,the CKD-EPI and EPI-Asia equations can reflect the eGFR of healthy young and middle-aged population accurately,the correlation and consistency among them were good.The eGFR between males and females have significantly difference（P＆lt;0.01）.eGFR was negatively correlated with age,eGFR（mL/min·1.73m2）=-0.892×age＋152.8（r2=0.651,P＆lt;0.01）.EPI-Asia was optimal equation,by which we establish of the eGFR reference interval（unit：mL/min·1.73 m2）in different gender and age groups：for males group：18-29years old（107.0-151.7）,30-39years（92.7-128.5）,40-49years（94.5-123.1）and 51-59years（88.3-115.2）;females group： 18-29years（120.6-162.5）,30-39years（113.9-139.0）,40-49years（95.5-127.8）and 50-59years（90.9-113.2）.Conclusion The results of this survey provide a reference for the proper use of eGFR equations.

关 键 词：肾小球滤过率 参考区间 湖南 

分 类 号：R692[医药卫生—泌尿科学]