红霉素对Langendorff灌流豚鼠心脏电活动的影响  

Effect of erythromycin on the langendorff perfused model of heart in guinea pigs

作　　者：王俊杰[1] 黄延红[1] 杜晶[1] 颜红[1] 亚白柳[1] 刘文彦[1] 

机构地区：[1]济宁医学院基础学院,山东济宁272067

出　　处：《济宁医学院学报》2013年第5期333-335,共3页Journal of Jining Medical University

基　　金：2011年济宁医学院青年科研基金(JYQ2011KM019)

摘　　要：目的研究红霉素对langendorff灌流豚鼠心脏电活动的影响。方法常规心电图记录法,观察红霉素对豚鼠离体心电图的作用。结果红霉素可延长豚鼠心电图PR间期、QT间期,增大QTc,减慢心率。0.3mmol/L红霉素可使PR间期从(66.1±3.2)ms延长到(92.3±10.7)ms(P<0.05);R波从(16.1±1.2)ms增宽至(18.1±3.7)ms(P<0.05);QT间期和QTc分别从(184.3±13.8)ms和(10.6±0.6)ms增加到(250.7±27.6)ms和(13.1±1.7)ms,(P<0.01,P<0.01);RR间期延长22.5%;心率减慢17.1%。较高浓度红霉素作用下,可出现室上性期前收缩。结论红霉素可减慢兴奋在心脏的传导,诱发室上性期前收缩等心律失常。Objective To explore the effect of erythromycin on the langendorff perfusion model of the heart in guinea pigs in vitro. Methods Electrocardiogram（ECG） was recorded using conventional ECG recording technique. Results Erythromycin prolonged PR interval, widened R wave,increased QT interval and QTc,and slowed heart rate（HR）in ECG. 0.3 mmol/L erythromycin prolonged PR interval to be（92.3 ± 10.7） ms from（66.1 ± 3.2） ms, prolonged 39.4 % （ F= 35.9, P 〈 0.05 ） ; width of R wave was widened from （ 16.1 ± 1.2 ） ms to （ 18.1 ± 3.7 ） ms, widened 12.4% （F=9.4 ,P〈0.05） ;QT interval and QTc were increased from（184.3± 13.8）ms and 10.6±0.6 to be（250.7 ±27.6） ms and 13.1 ± 1.7 respectively; RR interval was prolonged 22.5 % （ F= 47.8, P〈0.05） ; HR was decreased 17.1 （ F= 40.5, P〈0.05）. Supraventricular premature contraction occurred with higher dose. Con- clusion Erythromycin could slow speed of excitation conduction in the heart,and lead to arrhythmia such as su- praventricular premature contraction.

关 键 词：红霉素 心电图 心律失常 

分 类 号：R965[医药卫生—药理学]