四种穿心莲二萜内酯类化合物的生物转化  

Biotransformation of 4ent-labdane diterpenoid lactones of Andrographis paniculata:recent progress

作　　者：王杰华[1] 王峥涛[1,2] 王莉莉[1] 王浙健[1] 马昭[1] 胡之璧[1] 黎万奎[1] 

机构地区：[1]上海中医药大学中药研究所,中药新资源与质量标准综合评价国家中医药管理局重点研究室,上海201210 [2]上海中医药大学中药研究所,中药标准化教育部重点实验室,上海201210

出　　处：《第二军医大学学报》2013年第10期1130-1136,共7页Academic Journal of Second Military Medical University

基　　金："十二五"国家科技支撑计划课题(2012BAI29B02)~~

摘　　要：穿心莲二萜内酯类化合物是穿心莲的特征性成分,具有抗菌、抗病毒、抗炎、解热和抗癌等广泛的药理作用。本文主要从转化底物及转化涉及的反应类型、转化体系、转化产物的构效关系等三方面综述了4种穿心莲二萜内酯在生物转化方面的研究情况,并就目前存在的问题及前景展望进行简要陈述,以期为进一步研究穿心莲二萜内酯类化合物的生物转化提供参考。Ent-labdane diterpenoid lactones, the principal constituents of Andrographis paniculata, have a wide range of pharmacological effects, such as antibacterial, anti-viral, anti-inflammatory, antipyretic, and anti-cancer effect, etc. In this review the biotransformations of four principal ent-labdane diterpenoid lactones of A. paniculata are discussed from the following aspects： substrates and types of reaction, transformation systems, and structure activity relationships. Moreover, the currently-existing problems and the prospects are also described to provide reference for further studying the biotransformation of ent-labdane diterpenoid lactones of A. paniculata.

关 键 词：穿心莲二萜内酯类 生物转化 中药化学 

分 类 号：R931.6[医药卫生—生药学]