维生素D与1型糖尿病患者β细胞功能的相关性分析  

Analysis of the correlation between vitamin D and β-cell function in type 1 diabetic patients

作　　者：吴冕[1] 陆俊茜[1] 黄艳[1] 郭凯锋[1] 于浩泳[1] 包玉倩[1] 陈海冰[1] 贾伟平[1] 

机构地区：[1]上海交通大学附属第六人民医院内分泌代谢科、上海市糖尿病研究所、上海市糖尿病重点实验室、上海市糖尿病临床医学中心,200233

出　　处：《中华内分泌代谢杂志》2013年第10期832-835,共4页Chinese Journal of Endocrinology and Metabolism

基　　金：国家自然基金面上项目（81070649）;2010年教育部“新世纪人才计划”

摘　　要：目的 分析1型糖尿病患者维生素D的水平,并探讨维生素D与1型糖尿病患者胰岛β细胞功能的关系。方法 选取2011年1月至2012年4月就诊的1型糖尿病患者65例、正常糖耐量者78例,以及HbA1C、血糖水平及糖尿病病程与1型糖尿病组匹配的2型糖尿病患者87例,比较3组之间血清25-羟维生素D3[25（OH）D3]水平的差别。将1型糖尿病组的空腹C肽水平与其他变量进行Pearson相关分析,然后将所有P〈0.05的因素纳入多元逐步直线回归分析。结果 1型糖尿病患者血清25（OH）D3水平显著低于正常糖耐量组及2型糖尿病组[7.7（4.8~14.9）对13.9（10.0~17.9）,12.5（9.3~17.4）ng/mg,均P〈0.01]。多元逐步直线回归分析显示1型糖尿病组空腹C肽浓度与25（OH）D3水平独立相关。结论 1型糖尿病患者维生素D水平显著低于正常糖耐量人群和2型糖尿病患者,1型糖尿病患者维生素D水平与β细胞功能呈独立正相关,对1型糖尿病患者是否需补充维生素D是一个值得研究的课题。Objective To determine vitamin D levels in patients with type 1 diabetes mellitus（T1DM）, and to explore the relationship of vitamin D and pancreatic β-cell function in these patients. Methods Sixty-five patients with T1DM, 78 controls with normal glucose tolerance（NGT）, as well as 87 type 2 diabetes mellitus（T2DM）patients, whose HbA1C, blood glucose levels, and duration of diabetes were matched with those in the T1DM group, were enrolled from January 2011 to April 2012. The differences in serum 25-hydroxyvitamin D3[25（OH）D3] levels among the three groups were compared. Pearson correlation analysis was used for investigating the relationship between fasting C-peptide levels and other variables in T1DM group, all P〈0.05 variables then were included in a stepwise multiple linear regression analysis. Results Serum 25（OH）D3 levels were significantly lower in T1DM group than those in NGT and T2DM groups[7.7（4.8-14.9）vs 13.9（10.0-17.9）,12.5（9.3-17.4）ng/mg, both P〈0.01]. Stepwise multiple linear regression analysis showed that fasting serum C-peptide concentration was independently associated with serum 25（OH）D3 level in T1DM group. Conclusions T1DM patients had lower vitamin D levels than NGT and T2DM subjects, vitamin D status showed independently a positive association with β-cell function in T1DM patients. Whether supplement of vitamin D to TIDM patients is a topic worth studying.

关 键 词：维生素D 糖尿病  1型 Β细胞功能 

分 类 号：R587.1[医药卫生—内分泌]