工作场所空气中二甲氧基甲烷职业接触限值的研制  

Study on occupational exposure limit of dimethoxymethane in workplace air

作　　者：陈浩[1] 林琳[1] 张茂棠[1] 刘渠[1] 李刚[1] 于碧鲲[1] 崔鹂[1] 

机构地区：[1]深圳市龙岗区疾病预防控制中心,518172

出　　处：《中华劳动卫生职业病杂志》2013年第10期787-791,共5页Chinese Journal of Industrial Hygiene and Occupational Diseases

摘　　要：目的 研制工作场所空气中二甲氧基甲烷的职业接触限值.方法 收集二甲氧基甲烷的理化性质、毒理学资料、职业流行病学研究资料,在分析以上资料的基础上,按照工作场所有害因素职业接触限值研制的原则及方法,制订工作场所空气中二甲氧基甲烷的职业接触限值.结果 二甲氧基甲烷生产企业采集165份空气样品,其中14份样品二甲氧基甲烷浓度超过3000 mg/m^3,占全部样品8.48％；当暴露浓度大于6000 mg/m^3时,暴露员工的不适症状发生率与对照组相比明显增加（P＜0.01）；各暴露组与对照组间的健康检查异常结果构成比差异无统计学意义（P＞0.05）.结论 建议将我国工作场所空气中二甲氧基甲烷的时间加权容许浓度（PC-TWA）定为3100 mg/m^3.该标准的安全性符合毒理学和职业流行病学的相关要求,同时较好地契合了我国现有的经济技术水平,在国内有较好的适用性.Objective To study the occupational exposure limit of dimethoxymethane （DMM） in workplace air.Methods Literature research was conducted on DMM; information on its physicochemical properties,toxicology,and occupational epidemiology was collected.Upon analyzing these data,an occupational exposure limit of DMM in workplace air was proposed according to the guidelines and principles of developing occupational exposure limits for harmful factors in workplaces.Results A total of 165 air samples were collected from DMM manufacturers,14 of which had a DMM concentration over 3000 mg/m^3,accounting for 8.48% of all samples.Compared with the control group,the exposed employees had a significantly increased incidence of discomfort symptoms when exposed to more than 6000 mg/m^3 DMN （P〈0.01）.No significant differences in the constituent ratios of abnormal results in physical examinations were found between the exposure groups and control group （P〉0.05）.Conclusion We recommend to set the permissible concentration-time weighed average to 3100 mg/m^3 as the occupational exposure limit of DMM in workplace air in China.This occupational exposure limit standard meets the relevant requirements of toxicology and occupational epidemiology,as well as fits well with our country＇ s current economical and technological levels.This standard has high applicability in China＇s domestic settings.

关 键 词：二甲氧基甲烷 职业接触限值 

分 类 号：R134.4[医药卫生—劳动卫生]