兔迷走神经在协调消化间期胆囊与奥迪氏括约肌运动方面的作用  

THE VAGUS NERVE COORDINATES THE MOTION OF GALLBLADDER AND SPHINCTER OF ODDI IN THE INTERDIGESTIVE PERIOD IN RABBITS

作　　者：刘传勇[1] 刘京璋[1] 李自英[1] 刘克敬[1] 

机构地区：[1]山东医科大学生理教研室,济南250012

出　　处：《中国应用生理学杂志》2000年第4期347-349,共3页Chinese Journal of Applied Physiology

基　　金：山东自然科学基金资助项目!(Y95c10 32 )

摘　　要：目的 :探讨兔迷走神经在协调消化间期胆囊 (GB)与奥迪氏括约肌 (SO)运动方面的作用。方法 :动物禁食但自由饮水 15～ 18h后 ,乌拉坦静脉麻醉。蛙膀胱置入GB内 ,测GB内压 ,双极康铜丝电极引SO肌电。结果 :消化间期GB位相性收缩 (GBPC)与SO锋电位簇 (CSPSO)间存在 1∶1对应关系 ,迷走复合区 (DVC)内微量注射谷氨酸钠 (MSG)或促甲状腺素释放激素 (TRH)后PCGB及SO锋电位活动增强 ,GBPC与CSPSO间 1∶1关系依然存在 ;颈部迷走神经切断或静脉注射阿托品后 ,PCGB及SO锋电位活动明显减弱 ,PCGB与CSPSO间对应关系消失 ;人为升高胆囊内压 ,SO锋电位无变化。结论Aim: To investigate the effect of vagus nerve on coordinating the motion of gallbladder (GB) and sphincter of Oddi (SO) in the interdigestive period in rabbits. Methods: Fasted for 15 h～18 h, but allowed to drink water, the rabbib were anesthetized with urethane (1.0 mg/kg, iv). In order to measure GB pressure, a frog bladder filled with normal saline was put into GB and connected to a transducer (TP 200T). Myoelectric signals of SO was recorded by a pair of copper electrodes. Results: In the interdigestive period, phasic contractions of GB (PCGB) and clusters of spike potentials of SO (CSPSO) was 1∶1 correlated ( Y =0.962X+0.587, r = 0.982 , P <0.01). That is, every PCGB was accompanied by one CSPSO. Microinjection of thyrotropin releasing hormone (TRH, 0.8 nmol, 1 μl) or monosodium glutamate (MSG, 2 μmol, 1 μl) into dorsal vagal complex (DVC) enhanced the motility of GB and SO, and the 1∶1 temporal relation between PCGB and CSPSO still existed. Vagotomy or intravenous injection of atropine inhibited the PCGB and the spike potentials of SO, and the 1∶1 correlation between PCGB and CSPSO disappeared. The spike bursts of SO did not respond to the artificial rise of gallbladder pressure. conclusion: In the interdigestive period in rabbits, gallbladder and SO contract and relax rhythmically and simultaneously. This eoordinated motion between GB and SO is controlled by DVC via vagus nerve and peripheral M receptors.

关 键 词：胆囊 奥迪氏括约肌 迷走神经 协调消化 

分 类 号：R333.3[医药卫生—人体生理学] R338[医药卫生—基础医学]