晚卵泡期孕酮水平升高增加卵裂期胚胎移植异位妊娠风险  

Elevated Progesterone Level at the End of the Follicular Phase Increased Ectopic Pregnancy Risk in Day 3 Embryo Transfer

作　　者：李蕊蕊[1] 郭艺红[1] 孙莹璞[1] 苏迎春[1] 李婧[1] 

机构地区：[1]郑州大学第一附属医院生殖医学中心,郑州450002

出　　处：《生殖与避孕》2013年第10期682-685,共4页Reproduction and Contraception

摘　　要：目的:探索晚卵泡期孕酮(P)水平升高与体外受精(IVF)卵巢期胚胎移植异位妊娠风险的关系。方法:回顾性分析行IVF卵裂期胚胎移植或囊胚移植并获得妊娠的1 508个周期异位妊娠发生情况。根据hCG注射日P水平分为P正常组(P≤1.5 ng/ml)与P升高组(P>1.5 ng/ml),比较组间的异位妊娠发生率。结果:卵裂期胚胎移植P正常组、P升高组异位妊娠率分别为2.8%(32/1 132)和7.9%(11/140),差异有统计学意义(P=0.005)。囊胚移植P正常组、P升高组异位妊娠率分别为1.5%(3/199)和5.4%(2/37),组间差异无统计学意义(P>0.05)。结论:晚卵泡期P升高可增加IVF卵裂期胚胎移植异位妊娠风险。Objective： To explore the association of elevated progesterone （P） level in late-follicle phase and ectopic pregnancy after in vitro fertilization （IVF）. Methods： A total of 1 508 cycles of ectopic pregnancy after d 3 embryo transfer or blastocyst transfer were retrospectively analyzed. All patients were divided into normal P group （P ≤ 1.5 ng/ml） and elevated P group （P〉1.5 ng/ml） according to the P level on the day ofhCG injection. The ectopic pregnancy rate was compared between the two groups. Results： Elevated P level at the end of the follicular phase significantly increased ectopic pregnancy rate in d 3 embryo transfer compared with normal P group （2.8% vs 7.9%, P=0.005）. No significant difference was observed in ectopic pregnancy rate of blastocyst transfer between the two groups （1.5% vs 5.4%, P=0.14）. Conclusion： Elevated P level at the end of the follicular phase increases ectopic pregnancy risk in d 3 embryo transfer but has no effect on blastocyst transfer.

关 键 词：体外受精-胚胎移植(IVF-ET) 异位妊娠 孕酮(P) 卵裂期胚胎 囊胚 

分 类 号：R714.8[医药卫生—妇产科学]