铜绿假单胞菌血液感染患者的病死率及危险因素分析  

Analysis of the risk factors for mortality in patients with bacteremia caused by Pseudomonas aeruginosa

作　　者：张昭勇[1] 杨宏伟[1] 娄国平[1] 张吉才[1] 

机构地区：[1]湖北医药学院附属太和医院检验部,湖北十堰442000

出　　处：《热带医学杂志》2013年第8期999-1001,1014,共4页Journal of Tropical Medicine

摘　　要：目的分析铜绿假单胞菌血液感染的病死率及影响患者死亡的相关因素。方法调查某院2008-2012年铜绿假单胞菌血液感染患者的病死率,收集患者的流行病学资料进行单因素分析,选择有意义的变量进行多因素非条件回归分析,确定影响患者病死的危险因素。结果 142例铜绿假单胞菌菌血症患者30d的病死率为37.32%。血液感染患者中最常见的原发感染部位是泌尿道(35.21%)。Logistic回归分析显示,血小板减少症(OR=4.599,95%C.I1.943～10.883)和不适当的初始抗菌治疗(OR=3.987,95%C.I1.746～9.102)是患者30d病死率的独立危险因素。结论铜绿假单胞菌血液感染患者病死率高,血小板减少症和不适当的初始抗菌治疗是影响其死亡的重要因素。Objective To investigate the mortality of bloodstream infection patients caused by P.aeruginosa,and determine the risk factors of mortality.Methods This retrospective cohort study was conducted among patients with bacteremia due to P.aeruginosa from 2008 to 2012.The epidemiological data and mortality were collected.Univariate analysis was performed.The meaningful variables were analyzed by unconditional multivariate regression to determine the risk factors of mortality.Results The 30-day mortality rate among 142 patients with P.aeruginosa bacteremia was 37.32% .The most common primary site of infection was the urinary tract 35.21% .Logistic regression analysis showed the thrombocytopenia （OR=4.599,95% CI 1.943～10.883）and initial inappropriate antibiotic therapy （OR=3.987,95%CI 1.746～9.102）were independent risk factors for mortality.Conclusion The patients with P.aeruginosa bloodstream infection had a high mortality rate,thrombocytopenia and initial inappropriate antimicrobial therapy is an important risk factor for mortality.

关 键 词：血液感染 铜绿假单胞菌 病死率 危险因素 

分 类 号：R515.9[医药卫生—内科学]