汕头地区下呼吸道感染肺炎链球菌的耐药性监测  

Monitoring of lower respiratory tract infecting drug resistant Streptococcus pneumonia in Shantou area

作　　者：陈小晶[1] 柯永坚[1] 朱红军[1] 陈爱媌[1] 

机构地区：[1]广东省汕头市中心医院检验科,广东汕头515031

出　　处：《热带医学杂志》2013年第8期1007-1008,1023,共3页Journal of Tropical Medicine

摘　　要：目的监测汕头地区下呼吸道感染肺炎链球菌(SP)的耐药性,为临床合理使用抗菌药物提供依据。方法收集汕头地区5家医院2010-2012年从下呼吸道标本中分离的296株肺炎链球菌,采用K-B纸片扩散法及E-test法进行常用抗菌药物敏感试验,分析其耐药特征。结果 296株肺炎链球菌对青霉素不敏感率为43.2%,其中耐青霉素肺炎链球菌(PRSP)为27.7%、青霉素中介肺炎链球菌(PISP)为15.5%。未检出对万古霉素、莫西沙星、利奈唑烷耐药的菌株。对红霉素的耐药率最高,为90.5%。14岁以下患者PRSP检出率为42.9%,高于成人组的24.2%;对头孢噻肟的耐药率为46.4%,亦高于成人组的13.3%,差异有统计学意义。结论汕头地区青霉素不敏感肺炎链球菌(PNSP)检出率高于其他地区,其对大环内酯类等药物耐药状况极为严峻。儿童对青霉素和头孢噻肟的耐药率高于成人。Objective To evaluate the drug resistance of Streptococcus pneumonia from the lower respiratory.Methods 296 Streptococcus pneumonia isolates were collected from five hospitals in the Shantou area between 2010 and 2012.K-B disk diffusion method and E-test were used to determine the susceptibility of Streptococcus pneumonia.Results 43.2% of the isolates were not sensitive to penicillin.27.2% of the isolates were resistant to penicillin resistant Streptococcus pneumonia （PRSP） and 15.5% of the isolates were resistant to penicillin-intermediate Streptococcus pneumonia （PISP）,Vancomycin,moxifloxacin and linzolid resistant strains were not found.90.5% of the isolated were resistant to erythromycin.PRSP rate of younger than 14 years is 42.9%,significantly higher than that of the PRSP rate of adults 24.2%.Conclusion The rate of penicillin-nonsusceptible Streptococcus pneumonia （PNSP） in Shantou area was much higher than the other areas.Resistance to macrolide antibiotics is especially serious.

关 键 词：下呼吸道感染 肺炎链球菌 耐青霉素肺炎链球菌 耐药性 

分 类 号：R378.12[医药卫生—病原生物学]