不孕不育患者生殖道支原体感染状况及耐药性分析  

Analysis of Ureaplasma urealyticum infection of genital tract and drug sensitivity in people with infertility problem

作　　者：刘晓莉[1] 樊凤艳[1] 赵瑞敏[1] 王照峰[1] 郑莉[2] 

机构地区：[1]空军总医院临床检验中心,北京100036 [2]南方医科大学公共卫生与热带医学学院,广东广州510515

出　　处：《热带医学杂志》2013年第8期1012-1014,共3页Journal of Tropical Medicine

摘　　要：目的探讨生育期不孕不育患者生殖道支原体感染现状及其药敏情况。方法将本院医学生殖中心2010年5月至2012年6月3579例不孕不育患者为不孕不育组,其中女性1494例,男性2085例,并将有过生育史的212例女性和265例男性作为对照组。取两组女性宫颈分泌物、男性尿道内分泌物、精液或前列腺液,采用微生物检验法进行支原体检测并对阳性患者进行药敏试验。结果不孕不育组支原体阳性率均显著高于对照组,其中男性不孕组阳性率为32.2%,对照组为5.3%;女性不孕组阳性率为57.5%,对照组为10.4%,差异均有统计学意义(P<0.01)。药敏结果显示:支原体对交沙霉素、美满霉素、强力霉素、克拉霉素药物敏感性高,耐药性低;而对氧氟沙星、左氧氟沙星、阿歧霉素、司帕沙星药物敏感性低,耐药性高。结论不孕不育患者的生殖道支原体感染率较高,在其治疗中应关注此项[1],并参考药敏试验结果合理用药,提高治愈率。Objective To study the genital tract infection and drug sensitivity of Ureaplasma urealyticum （UU） in young people with infertility problem.Methods Samples from 3 579 subjects （1 494 female and 2 085 male） with infertility problem were collected between May 2010 and June 2012.212 normal subjects with the history of pregnancy and 265 male subjects were selected as control.Samples were collected from the cervical secretions or from the urethral secretions,semen and prostatic fluid.Drug sensitivity test was performed on the patients with positive test for mycoplasma.Results The UU positive rate of the patients was higher than the healthy subjects.In the male infertility group,the UU positive rate was 32.2% when compared with the control group （5.3%）.In the female infertility group,the UU positive rate was 57.5% when compared with the control group （10.4%）.The differences were statistically significant （P＆lt;0.01）.UU was found to be more sensitive to josamycin,hydrochloridedoxycycline and clarithromycin.UU was less sensitive to ofloxacin,levofloxacin,azithromycin and sparfloxacin.Conclusions People with infertility problem had a high frequency of genital tract infection with Ureaplasma urealyticum.The pathogens should be tested for the drug sensitivity before treatment.

关 键 词：不孕不育 支原体 药物敏感试验 

分 类 号：R375[医药卫生—病原生物学]