基于流动注射的高速医用电解质分析模块研制  

Development of High-Speed Medical Electrolyte Analyzer Based on Flow Injection

作　　者：张会生[1] 张小飞[1] 刘昕宇[1] 饶捷[1] 钟彩青 李乔亮[1] 齐素文[1] 林淑梅[1] 陈思平[1] 汪天富[1] 

机构地区：[1]广东省生物医学信息检测与超声成像重点实验室,深圳大学生物医学工程系,深圳518000 [2]深圳市新产业生物医学工程股份有限公司,深圳518000

出　　处：《中国生物医学工程学报》2013年第5期562-571,共10页Chinese Journal of Biomedical Engineering

基　　金：国家自然科学基金(81000637;61031003);广东省育苗工程(2012LYM_0114)

摘　　要：面向全自动生化分析仪的电解质测试需求,结合流动注射分析法(FIA)与离子选择电极法(ISE),在理论上对动态的电解质分析方法进行分析讨论,为电解质模块的研发提供了理论基础。利用嵌入式技术实现模块的研制,并进行电解质测量实验,对模块的准确度、精密度、线性、稳定性、交叉污染率等5个方面进行评价,实验结果显示,K+、Na+、Cl-相对偏差和交叉污染率均在1%之下,变异性系数分别为0.40%、0.22%、0.66%,线性误差分别为-1.10%、-0.68%、-0.46%,稳定性分别为1.11%、0.76%、1.39%。临床实验结果表明,该电解质模块可以满足临床应用的要求。与传统电解质分析仪相比,该电解质模块可与全自动生化分析仪联用,测试速度高达150样品/h,在高速电解质分析领域具有一定的应用前景。To meet the demand of automatic biochemical analyzer electrolyte test, a flow injection dynamic ion analysis method was proposed based on method and experiments in this paper. The new method took advantages of flow injection analysis （FIA） and ion selective electrode （ISE）. With embedded technology, we developed a new electrolyte module and tested its accuracy, precision, stability and cross contamination. Experiment results showed that the relative deviation and cross contamination of K ~, Na ＋ and C1- were under 1% ; the coefficient of variability respectively was 0.40%, 0.22% and 0.66% respectively; linearity error was - 1.10% , -0.68% and -0.46% respectively; And stability was 1.11% , 0.76% and 1.39% respectively. The clinical results showed that the electrolyte module met the requirement of the clinical application. Compared with conventional electrolyte analyzer, this module can be applied together with automatic biochemical analysis instrument; moreover, its test speed reached 150 samples/h, which allows it to be used in the field of high-speed electrolyte analysis.

关 键 词：全自动生化分析仪 流动注射分析法（FIA） 离子选择电极法（ISE） 高速电解质分析仪 

分 类 号：TP202[自动化与计算机技术—检测技术与自动化装置]