过氧化物酶体增殖物激活受体γ在骨关节炎发生机制中的作用研究进展  

Progress in role of peroxisome proliferator-activated receptor γ in pathogenesis of osteoarthritis

作　　者：罗瀚文[1] 汪晖[2] 王林龙[1] 谭杨[1] 陈廖斌[1] 

机构地区：[1]武汉大学中南医院骨科,湖北武汉430071 [2]武汉大学基础医学院药理学系,湖北武汉430071

出　　处：《中国药理学与毒理学杂志》2013年第5期872-875,共4页Chinese Journal of Pharmacology and Toxicology

基　　金：国家自然科学基金重大国际合作项目(81220108026);国家自然科学基金(30973539)~~

摘　　要：过氧化物酶体增殖物激活受体γ(PPARγ)是一种由多种脂肪酸及其衍生物激活的核转录因子,通过调节胆固醇流出系统、瘦素、脂联素及多种炎症因子,在机体脂代谢、炎症反应和细胞凋亡中发挥重要作用。骨关节炎的主要病理改变是关节软骨退行性变、软骨边缘骨质增生及骨赘形成,其发生机制与脂代谢、炎症反应和细胞凋亡的关系紧密。PPARγ可能通过调控上述因素,参与骨关节炎的发生发展,而PPARγ激动剂则具有纠正脂代谢紊乱、抗炎和抗凋亡作用,有望成为治疗骨关节炎的新一代药物。本文综述了PPARγ在OA发生过程中调节脂代谢、抗炎和抗凋亡中的重要作用。Peroxisome proliferator-activated receptor y（PPARγ） is a nuclear transcription factor which can be activated by a variety of fatty acids and their derivatives. It plays an important role in lipids metabolism, inflammatory response and apoptosis by regulating cholesterol efflux, leptin, adiponectin and inflammatory cytokines. Pathological changes of osteoarthritis involve degeneration of the articular cartilage and cartilage edge hyperostosis, and osteophyte formation, leading to joint pain and limited mobility. The pathogenesis of osteoarthritis is closely related to lipid metabolism, inflammatory and apoptosis, PPARγ, may participate in the development of osteoarthritis through regulation of the above factors. The aloility of PPARγ agonist to correct lipid metabolism plus its anti-inflammatory and anti-apoptotic effect makes it a new drug for the treatment of osteoarthritis.

关 键 词：过氧化物酶体增殖物激活受体Γ 骨关节炎 脂代谢 炎症 细胞凋亡 

分 类 号：R684.3[医药卫生—骨科学]