MicroRNA对胚胎干细胞的多能性网络调控  

The effect of microRNAs on the regulatory network of pluripotency in embryonic stem cells

作　　者：白银山[1] 李莉[1] 卫恒习[1] 朱翠[1] 张守全[1] 

机构地区：[1]华南农业大学动物科学学院,动物基因组与分子育种广东省重点实验室,广州510642

出　　处：《遗传》2013年第10期1153-1166,共14页Hereditas（Beijing)

基　　金：国家重点基础研究发展计划(973计划)项目(编号:2011CB944202;2010CB945001);国家科技支撑计划(编号:2011BAD19B03)资助

摘　　要：胚胎干细胞(Embryonic stem cells,ESCs)是一类能够无限增殖和诱导分化为多种类型细胞的干细胞。MicroRNA(miRNA)是一类内源性具有调控基因表达功能的非编码RNA,在ESCs增殖和分化过程中起重要作用。MiRNA可以通过对ESCs多能性网络中的转录因子、细胞周期、表观遗传学、信号转导等方面调控,促使ESCs维持多能性状态。文章重点综述了miRNA的生成过程、调控ESCs多能性的主要miRNA家族以及miRNA对ESCs多能性网络调控作用等内容。Embryonic stem cells （ESCs） are pluripotent stem cells characterized by their ability to self-renew and their pluripotency to differentiate into all cell types. MicroRNA （miRNA） is a small non-coding RNA molecule which can regu- late transcriptional and post-transcriptional gene expression, and may also play significant roles in regulating proliferation and differentiation of ESCs. The maintenance of pluripotency in ESCs may involve a regulatory network of many factors and pathways regulated by miRNA, which includes ESCs transcription factors, cell cycle regulation, epigenetic modifica- tions as well as intracelluar signal transduction. This review mainly elaborates the biogenesis of miRNA, the miRNA fami- lies regulating the pluripotency of ESCs, and the effect of miRNA on the regulatory network of pluripotency in ESCs.

关 键 词：ESCS MIRNA 多能性 调控 

分 类 号：R329[医药卫生—人体解剖和组织胚胎学]