布托啡诺、曲马多及其复合应用在术后镇痛中的效果  

Outcomes of butorphanol,tramadol,or their combination for postoperative analgesia

作　　者：蒋金娣 韩传宝 周钦海 钱燕宁 桂波 

机构地区：[1]南京医科大学第一附属医院麻醉科,江苏省210029

出　　处：《江苏医药》2013年第20期2434-2436,共3页Jiangsu Medical Journal

摘　　要：目的比较布托啡诺、曲马多及两药联合应用在术后自控静脉镇痛(PCIA)中的临床效果。方法拟行择期腹部手术患者90例随机均分为布托啡诺组(B组)、曲马多组(T组)和布托啡诺复合曲马多组(BT组),记录术后4、24、48h的VAS、Ramsay镇静评分、舒适度评分、追加镇痛药例数、镇痛泵按压次数和不良反应发生情况。结果与BT组相比,B组术后4、24h的VAS降低,Ramsay评分升高,术后4h镇痛泵按压次数减少(P<0.05),T组术后24h的VAS降低(P<0.05)。结论复合应用布托啡诺与曲马多PCIA的镇痛效果不及各自单一药物,且未减少不良反应的发生。Objective To compare the outcomes of butorphanol, tramadol, and their combination in postoperative patient-controlled intravenous analgesia （PCIA）. Methods Ninety patients scheduled for abdominal surgeries and undergoing PCIA were equally randomized into three groups of B（butorphanol）, T （tramadol） and BT （ butorphanol combined with tramadol）. VAS pain score, Ramsay sedative score, Bruggrmann comfort scale score, the numbers of receiving rescue medication and PCA button pressing and analgesia-related adverse reaction were compared at 4,24 and 48 h after surgery among three groups. Results Compared with group BT, VAS pain scores were lower and Ramsay scores were higher at 4 h and 24 h, and PCA numbers were less within 4 h in group B（P（0. 05）. Compared with group BT, VAS pain score was lower in group T at 24 h after surgery（P^0. 05）. Conclusion The efficacy of combined use of butorphonal and tramadol has no better analgesic effect and less adverse reactions than that of butorphonal or tramadol alone for PCIA.

关 键 词：布托啡诺 曲马多 自控静脉镇痛 

分 类 号：R614[医药卫生—麻醉学]