福建沿海地区正常高值血压及高血压人群现况及其心血管危险因素的调查  

Cardiovascular disease risk and vascular damage status in pre-and hypertension population in coastal areas of Fujian province

作　　者：黄峰[1] 朱鹏立[1] 肖华贞[1] 林帆[1] 袁音[1] 郜忠海[2] 李建卫[3] 陈发林[4] 

机构地区：[1]福建省立医院老年科福建省临床老年病研究所福建医科大学省立临床医学院,福州350000 [2]福建省立医院眼科 [3]福建省立医院超声诊断科 [4]福建省立医院临床检验中心

出　　处：《中华心血管病杂志》2013年第10期876-881,共6页Chinese Journal of Cardiology

基　　金：福建省科技基本计划重点项目（2010Y0013）

摘　　要：目的 调查福建沿海某地区正常高值血压和高血压人群心血管危险因素和全身血管损伤情况.方法 横断面调查福建沿海某地区30岁以上人群3344例,行糖脂、尿酸、尿微量蛋白、肱踝脉搏波速度（baPWV）和视网膜中央动脉直径（CRAE）等检测,采用方差分析和logistic回归分析正常高值血压和高血压人群危险因素及血管损伤情况.结果 （1）调查地区年龄标化后正常高值血压人群占总调查人群比例和年龄标化后高血压的患病率均为30.0％；高血压人群65.5％ （909/1388）合并3种及以上心血管危险因素,正常高值血压人群37.5％（330/880）合并3种及以上心血管危险因素.（2）高血压和正常高值血压人群UACR、baPWV、CRAE异常发生率分别为25.7％ （357/1388）、84.2％ （1169/1388）、29.5％ （409/1388）和20.0％ （176/880）、29.1％ （256/880）、25.6％（225/880）,较正常血压人群异常发率生8.5％（91/1076）、8.9％（96/1076）、18.8％（202/1076）均明显升高（P均＜0.05）.（3）logistic回归示正常高值血压和高血压是UACR、baPWV、CRAE的独立相关因素,正常高值的OR值和95％可信区间分别为1.496（1.095 ～2.044）、2.477（1.815～3.381）、0.700（0.549 ～0.891）,高血压的OR值和95％可信区间分别为1.976（1.454～2.686）、17.707（12.938～24.235）、0.591 （0.474 ～0.736）.结论 福建省沿海地区正常高值血压和高血压人群合并多种心血管危险因素,正常高值血压和高血压血管损伤风险较正常血压人群明显升高.Objective To observe the cardiovascular risk factors and vascular damage status of preand hypertentsive population in the coastal areas of Fujian province.Methods This cross-sectional study surved 3344 Fujian coastal people aged older than 30 years.Glycolipids,uric acid,urine,microalbumin,brachial-ankle pulse wave velocity （baPWV） and central retinal arteriolar equivalent（CRAE） measurements were performed.Variance analysis and binary logistic regression were applied to evaluate cardiovascular risk factors and vascular damage of prehypertensive as well as hypertensive population.Results （1） The morbidity of prehypertension as well as hypertension was 30.0% in coastal population of Fujian Province,there were more than 3 cardiovascular risk factors in 65.5% （909/1388） of the hypertensive population and 37.5% of the prehypertensive population.（2） The abnormal rates of creatinine ratio（UACR）,baPWV,and CRAE in hypertensive [25.7% （357/1388）,84.2% （1169/1388）,29.5% （409/1388）] and prehypertensive population [20.0% （176/880）,29.1% （256/880）,25.6% （225/880）] were significantly higher than those of normotensive individuals [8.5% （91/1076）,8.9% （96/1076）,18.8%（202/1076）,all P 〈 0.05].（3） Prehypertension and hypertension served as independent risk factors of UACR,baPWV and CRAE according to logistic regression analysis.The odds ratios （OR） value and 95% confidence intervals were 1.496 （1.095-2.044）,2.477 （1.815-3.381）,0.700 （0.549-0.891） in prehypertensive population,and 1.976 （1.454-2.686）,7.707 （12.938-24.235）,0.591 （0.474-0.736） in hypertensive population.Conclusion Multiple cardiovascular risk factors coexist in prehypertensive and hypertensive population in the coastal area of coster areas of Fujian province and there is more morbidity of vascular damage in prehypertensive and hypertensive individuals compared to normotensive subiects in these areas.

关 键 词：高血压 危险因素 流行病学 

分 类 号：R544.1[医药卫生—心血管疾病]