围手术期癌症患者焦虑对免疫功能的影响  

Influence of anxiety on the immune function of patients with cancer during perioperative period

作　　者：何柳[1] 周小青[1] 梁丽梅[1] 凌朝灵[1] 王宁莉[1] 

机构地区：[1]右江民族医学院附属医院手术室,广西百色533000

出　　处：《右江医学》2013年第5期640-642,共3页Chinese Youjiang Medical Journal

基　　金：广西卫生厅科研资助项目(Z2012723)

摘　　要：目的探讨癌症患者焦虑对免疫功能的影响。方法采用焦虑自评量表(SAS)进行评定,以围手术期合并焦虑的96例癌症患者为研究对象(焦虑组,其中轻度焦虑组45例,中度焦虑组31例,重度焦虑组20例),以非焦虑的癌症手术患者42例作为对照组,用流式细胞仪检测患者外周血T、B、NK淋巴细胞亚群的水平。结果焦虑组患者CD3+、CD3+CD4+、CD4+/CD8+和CD3-CD19+水平显著低于非焦虑组(P<0.01),而CD3+CD8+和CD3-CD56+水平显著高于非焦虑组(P<0.01),并且CD3+、CD3+CD4+、CD4+/CD8+和CD3-CD19+水平在不同焦虑程度患者存在显著性差异,随焦虑加重呈下降趋势,而CD3+CD8+和CD3-CD56+含量随焦虑加重呈上升趋势。结论癌症患者焦虑对机体免疫功能具有抑制作用,可作为评价机体免疫功能损害的一项指标,对预示癌症的发生或恶化具有重要预警价值。Objective To investigate the influence of anxiety on the immune function of patients with cancer during perloperative period.Methods 96 cancer patients with anxiety during perioperative period were evaluated by self rating anxiety scale（SAS）.Among the 96 patients,45 cases had light anxiety,31 cases had middle anxiety and 20 cases had heavy anxiety.42 cancer pa＊ien1s without anxiety were chosen as the control group.Then,levels of T,B and NK cell subpopulation were detected by flow cytometry. Results I.evels of CD3＋,CD3＋ CD4＋ ,CD4＋/CD8＋ and CD3 -CD19＋ in the anxiety group were significanlly lower than those in the control group（ P 〈0.01）,while levels of CD3＋ CD8t and CD3 CD56 ＋ were higher than those in the control group（ P 〈0.01）. Levels of CD3＋ ,CD3＋ CD4＋ , CD4＋ /CD8＋ and CD3- CD19＋ in the patients with different degrees of anxiety decreased with the aggravation of anxiety, while levels of CD3 ＋ CD8 ＋ and CD3 CDS6 ＋ increased wi＊h the aggravation of anxlety.Conelusion Anxiety of patients with cancer may inhibit immune function has inhibitory effect on the body＇s immune function, so it can be a-- dopted as an index of evaluation on immune function lesion and therefor has significant prewarming value in prognosti-cation of cancer occurrence or aggravation.

关 键 词：癌症 围手术期 焦虑 免疫功能 

分 类 号：R473.73[医药卫生—护理学]