透脓散阻止慢性胃溃疡病理性瘢痕形成的实验研究  

Experimental Research into Tounong Powder Preventing Formation of Chronic Peptic Ulcer Scar

作　　者：陈继兰[1] 张慧慧[1] 徐萌[1] 叶俏波[1] 黄秀深[1] 王良[2] 

机构地区：[1]成都中医药大学基础医学院,四川成都611137 [2]安岳县中医院医教科,四川安岳642350

出　　处：《南京中医药大学学报》2013年第5期448-451,共4页Journal of Nanjing University of Traditional Chinese Medicine

基　　金：成都中医药大学自然科学基金(ZRMS201233)

摘　　要：目的通过透脓散对大鼠慢性胃溃疡组织中生长激素(GH)、羟脯氨酸(Hyp)以及透明质酸酶(HAase)含量的影响,探讨托里透毒法优化成纤维细胞功能、阻止慢性胃溃疡病理性瘢痕形成的机制。方法采用乙酸烧灼型慢性胃溃疡模型,将大鼠分为空白对照组、模型组、透脓散高中低剂量组、西药对照组(奥美拉唑组、雷尼替丁组、达喜组)等8组,运用ELISA法测定各组胃组织GH、Hyp、HAase的水平。结果给药14天后,透脓散各剂量组与模型组相比,GH水平均有所降低,HAase水平均有所增高;透脓散高剂量组Hyp水平有所增高,而透脓散中剂量组和透脓散低剂量组Hyp水平有所降低。结论透脓散能降低溃疡组织的GH水平和Hyp水平、升高HAase水平,从而优化成纤维细胞功能达到阻止慢性胃溃疡病理性瘢痕形成的作用,而且其效应在某些方面优于西药。OBJECTIVE To investigate Tounong Powder＇s optimizing fibroblast＇s function and preventing the formation of chronic peptic ulcer scar through its effect on the content of growth hormone （GH）, hydroxyproline （Hyp） and hyaluronidase （HAase）. METHODS Acid burning chronic gastric ulcer model was established. The rats were divided into 8 groups： blank control group, model group, high, middle and low-dose of Tounong Powder groups, western medicine control groups （ome- prazole group, ranitidine group and Hydrotalcite group）. ELISA was applied to detect the GH, Hyp and HAase levels. RE- SULTS 14 days after administration, compared with model group, GH levels of all the Tounong Powder groups decreased, while HAase increased. Hyp of high-dose group went up, but in low and middle-dose groups it was reduced. CONCLUSION Tounong Powder lowers GH and Hyp levels and elevates HAase level, thereby optimizing fibroblast function to prevent chronic gastric ulcer scar shaped. Its effect in some respects is better than the control.

关 键 词：透脓散 慢性胃溃疡 瘢痕 生长激素 羟脯氨酸 透明质酸酶 

分 类 号：R285.5[医药卫生—中药学]