插管前追加小剂量异丙酚对气管插管条件的影响  

Effect of additional propofol on intubation conditions

作　　者：王灿琴[1] 金文杰[1] 

机构地区：[1]南京医科大学第一附属医院麻醉科,江苏南京210029

出　　处：《实用临床医药杂志》2013年第17期42-44,共3页Journal of Clinical Medicine in Practice

摘　　要：目的 探讨插管前追加小剂量异丙酚对气管插管条件的影响.方法 90例ASAⅠ～Ⅱ级择期行全麻气管插管手术的患者,根据麻醉诱导异丙酚用量及给药方式不同随机均分为A、B、C组,诱导时3组均使用芬太尼1.5 μg/kg,1min后给予异丙酚,A、B组为1.5μg/kg,C组为2μg/kg,间隔30 s后推注罗库溴铵0.6 μg/kg,45 s后B组加注异丙酚0.5 μg/kg,3组均于罗库溴铵注射90 s后行气管插管.比较气管插管的条件及血流动力学的改变.结果 B组气管插管条件明显优于A、C组；插管后3minC组MAP显著低于A、B组,A、B组MAP无显著差别.结论 气管插管前追加0.5 μg/kg异丙酚有利于提高气管插管条件,且不增加低血压的发生率.Objective To evaluate whether an additional dose of propofol prior to intubation improves intubation conditions. Method Ninety ASA physical status I and II patients undergoing elective surgery with general anesthesia were included in the study. Interventions： Patients received different doses of propofol （Groups A and B, 1.5 mg/kg; Group C, 2 mg/kg） preceded by fentanyl （1.5 /~g/kg）. In Group B, additional propofol （0.5 mg/kg） was administered 45 seconds after rocuronium. Intubation was performed 90 seconds after administration of rocuronium 0.6 rng/kg. Intubation conditions and hemodynamie variables were compared among the three groups. Results Intubation conditions were acceptable in 63.6 % of Group A, 36.4 % of Group C, and 93.3 % of Group B （P = 0. 005）. Mean arterial pressure （MAP） three minutes after intubation was signifi- cantly lower in Group C （P = 0. 006 vs. Groups A and B）, while MAP did not differ between Group A and Group B. Conclusion Administration of an additional dose of propofol （0.5 mg/kg） prior to intubation may significantly improve intubation conditions without increasing the frequency of hypotension.

关 键 词：异丙酚 气管插管条件 血压 

分 类 号：R768[医药卫生—耳鼻咽喉科]