复方异丙托溴铵和氨溴索雾化吸入在高龄肺部感染患者治疗中的应用价值比较  

Therapeutic comparison of compound ipratropium bromide aerosol inhalation and ambroxol aerosol inhalation in treatment of senile patients with pulmonary infection

作　　者：贺顺川[1] 于伟[1] 马雅心[1] 于芸菲[1] 张若男[1] 黄带发[1] 

机构地区：[1]沈阳军区总医院干二科,辽宁沈阳110840

出　　处：《实用临床医药杂志》2013年第19期91-94,共4页Journal of Clinical Medicine in Practice

摘　　要：目的 比较复方异丙托溴铵和氨溴索雾化吸入对干部病房高龄肺部感染患者症状改善的效果,探讨其对抗生素使用时间的影响及高龄患者对该药雾化吸入的耐受性.方法 选取诊断为肺炎或COPD加重期的高龄男性患者（年龄≥80岁）52例,随机分为治疗组和对照组.治疗组给予复方异丙托溴铵混悬液2.5mg雾化吸入,3～4次/d;对照组给予氨溴索30mg雾化吸入,3～4次/d;根据经验性用药及细菌培养结果来选用抗生素.比较2组的临床症状改善情况、抗生素使用时间、多药耐药发生情况、耐受性及副作用.结果 治疗组症状改善、血氧改善显著优于对照组（P＜0.05）;治疗组抗生素使用时间较对照组明显缩短（P＜0.05）,但2组多药耐药发生率无显著差异;雾化吸入异丙托溴铵、氨溴索均能明显提高通气能力,改善患者缺氧状态,2组比较疗效无明显差异;异丙托溴铵或氨溴索雾化吸入在高龄患者中耐受良好,2组不良反应发生率无显著差异（P＞0.05）.结论 与氨溴索雾化吸入比较,异丙托溴铵雾化吸入可更显著改善高龄肺部感染患者的临床症状,缩短抗生素使用时间,值得临床推广.Objective To compare the effect of compound ipratropium bromide aerosol in- halation and ambroxol aerosol inhalation on symptom improvement of senile patients with pulmonary infection in cadre ward, and to explore the influence of the two medicine on application duration of antibiotics and drug tolerance of senile patients with drug inhalation. Methods Fifty - two senile male patients （≥80 years old） diagnosed as pneumonia or aggravating phase of COPD were selected and randomly divided into treatment group and control group. The treatment group was treated with aerosol inhalation of compound ipratropium bromide aerosol, 2.5 mg for each time, 3 to 4 times for each day, and the control group was treated with aerosol inhalation of ambroxol, 30 mg for each time, 3 to 4 times for each day. Selection of antibiotics was based on empirical medication and result of bacterial culture. Situation of clinical symptom improvement, application duration of antibiotics, occurrence of multi- drug resistance, tolerance of patients and adverse reactions were compared between two groups. Results Clinical symptom improvement and blood oxygen improve- ment in the treatment group were significantly better than the control group （P 〈 0.05）, and appli- cation duration of antibiotics in the treatment group was significantly shorter than the control group （P 〈 0.05）. But there was no significant difference of incidence rate of multi- drug resistance be- tween two groups. Either ipratropium bromide aerosol inhalation or ambroxol aerosol inhalation was able to improve ventilation ability and state of hypoxia obviously, and the result showed that there was no significant difference of efficacy between two groups. Senile patients expressed favorable medication tolerance with aerosol inhalation of ipratropium bromide or ambroxol, and there was no significant difference of incidence rate of adverse reactions between two groups （P 〈 0. 05）. Conclusion Compared with ambroxol aerosol inhalation, ipratropium bromide aerosol in

关 键 词：高龄 肺部感染 复方异丙托溴铵 氨溴索 耐受性 

分 类 号：R563[医药卫生—呼吸系统]