内镜下5-FU化疗缓释粒子植入治疗食管癌的术中配合  

Care Assistance during Surgery for Esophageal Cancer Patients Undergoing Implantation of 5-Fluorouracil Sustained Release Particles

作　　者：何淑燕[1] 姚爱群[1] 江淮芝[1] 徐亚梅[1] 

机构地区：[1]蚌埠医学院第一附属医院消化内镜中心,安徽省蚌埠市233000

出　　处：《中华全科医学》2013年第11期1813-1814,共2页Chinese Journal of General Practice

摘　　要：目的通过对12例食管癌患者行内镜下缓释5-氟尿嘧啶(5-FU)粒子植入的术前、术中、术后护理及临床观察,初步探索和总结临床护理经验。方法将5-氟尿嘧啶化疗缓释粒子通过内镜活检孔道直接植入到食道肿瘤组织、瘤体周围间质中,每例用200 mg分次植入,每次7粒。对患者进行术前心理护理,术中配合,术后病情观察等。结果术后12例患者5-氟尿嘧啶粒子植入成功率100%,其中2例无效,10例进食梗阻症状明显缓解。治疗总有效率为83.3%。术后1个月复查胃镜显示肿瘤不同程度缩小,治疗效果较好。结论内镜下5-氟尿嘧啶化疗缓释粒子植入突出了局部靶向治疗,提高了肿瘤部位的药物浓度,为晚期食管癌的局部治疗寻找了一种新途径。经临床验证具有微创、安全、有效、毒副作用小的特点。Objective To preliminary explore and summarize the clinical nursing experience for esophageal cancer patients undergoing implantation of 5-fluorouracil（5-FU） sustained release particles. Methods Total 12 patients with esophageal cancer were enrolled in the study. The 5-fluorouracilsustained release particles were directly implanted into the esophageal tumor tissue and the tumor interstitial matrix via endoscopic biopsy channel ,7 tablets every time amount to 200 mg. Preoperative psychological nursing, perioperative coordination and postoperative observation of patient＇ s condition was assessed. Results The success rate of 5-fluoronracil implantation was 100%. 2 cases were invalid with a total effective rate of 83.3%. The efficacy was confirmed by endoscopy one month after the operation, the size of tumors contracted at some extent. Conclusion The implantation of 5-fluorou-racilsustained release particles into the esophageal tumor tissue can increase the content of drugs around the tumors, reveals the superiority of targeted therapy. This method is a minimally invasive, safe and effective method with a low toxic and side-effect.

关 键 词：食管癌 5-FU 缓释粒子 护理 

分 类 号：R473.73[医药卫生—护理学] R735.1[医药卫生—临床医学]