四川省细菌耐药监测网2012年川北地区细菌耐药性监测数据分析  

2012 annual report of Sichuan provincial bacterial resistance investigation net: bacterial resistance in the north Sichuan

作　　者：俞安清[1] 张韩[1] 何先伟[1] 苏丽萍[1] 张博林[1] 

机构地区：[1]四川省广元市中心医院检验科,四川广元628000

出　　处：《实用医院临床杂志》2013年第6期143-147,共5页Practical Journal of Clinical Medicine

摘　　要：目的了解四川省川北地区11家医院临床分离细菌对常用抗菌药物的耐药性。方法采用VITEK、Microscan、API或手工方法进行目标细菌鉴定。药敏实验采用K-B法、MIC法或E-TEST法,按照美国临床和实验室标准化协会(Clinical and Laboratory Standards Institute,CLSI)2012年版标准判断结果,以Whonet 5.6软件进行数据分析。结果 11家医院2012年各种临床标本中分离菌株共19740株,其中革兰阳性菌4989株(占25.3%),革兰阴性菌14751株(占74.7%)。葡萄球菌中MRSA和MRSCON检出率分别为21.6%和69.9%,未发现万古霉素、利奈唑胺不敏感葡萄球菌。粪肠球菌和屎肠球菌对万古霉素耐药率分别为1.1%和2.1%;对利奈唑胺耐药率分别为4.7%和1.9%。未发现利奈唑胺、万古霉素不敏感的肺炎链球菌。大肠埃希菌与肺炎克雷伯菌对亚胺培南的耐药率分别为0.2%和0.1%。铜绿假单胞菌和鲍曼不动杆菌对亚胺培南的耐药率分别为18.1%和59.5%。嗜麦芽窄食单胞菌对复方新诺明的耐药率为9.8%。结论川北地区临床分离细菌耐药现象较普遍,定期进行耐药性监测有助于了解细菌的耐药性,为临床医生合理用药提供参考。Objective To investigate the resistance of clinical bacterial isolates to commonly used antimicrobial drug in 11 hospitals of the north Sichuan. Methods Identification of target bacterial was performed by using VITEK, Microscan, API or manual method. Drug sensitivity testing was carried out by using K-B method, MIC method or E-TEST method. The results were determined ac-cording to the Clinical and Laboratory Standards Institute（ CLSI,2012 edition）. Statistical analysis was performed by using Whonet 5.6 software. Results 19,740 bacterial isolates were collected including 4,989 gram-positive bacteria,accounting for 25.3% and 14,751 gram-negative bacteria, accounting for 74. 7 %. The incidences of meticillin-resistant S. aureus （MRSA） and coagulase negative Staphy-lococcus （MRSCON）were 21.6% and 69. 9%, respectively. No vancomycin and linezolid resistant Staphylococcus strains were found. The incidences of vancomycin-resistant Faecalis and E. faecium were 1.1% and 2. 1%, respectively. The incidences of linezolid-resist-ance Faecalis and E. faecium were 4. 7% and 1.9%, respectively. No vancomycin and linezolid resistant Streptococcus pneumoniae was found. The incidences of imipenem-resistant E. coli and Klebsiella pneumoniae were 0. 2% and 0. 1%, respectively. The incidences of imipenem-resistant Pseudomonas aeruginosa and Baumanii were 18. 1% and 59. 5%, respectively. The incidence of SMZ-TMP-resist-ant Stenotrophomonas mahophilia was 9. 8%. Conclusion The bacterial resistance of clinical isolates is relatively common in the north Sichuan. Regular investigation of drug resistance is helpfui to find the resistance of bacteria and provide the reference for clinical ration-al drug choose.

关 键 词：细菌 耐药性 抗菌药物 药敏试验 

分 类 号：R372[医药卫生—病原生物学]