2型糖尿病患者血浆血管性血友病因子的表达及其与冠心病的关系  

Expression of plasma von Willebrand factor in T2DM patients and the analysis of its relationship with coronary heart disease

作　　者：张园 陆欣 金玮[2] 

机构地区：[1]内蒙古自治区人民医院心内科,内蒙古呼和浩特010010 [2]上海交通大学医学院附属瑞金医院心内科,上海200025

出　　处：《中国医药导报》2013年第30期54-56,60,共4页China Medical Herald

基　　金：国家自然科学基金项目(编号81070177)

摘　　要：目的探讨研究血管性血友病因子（vWF）水平在2型糖尿病患者（2TDM）的中变化及其与冠心病的关系。方法选取2010年1月～2013年1月内蒙古自治区人民医院收治的160例老年2型糖尿病患者为研究对象．根据2型糖尿病的诊断标准分为2型糖尿病合并冠心病组（2TDM＋CHD组）与单纯2型糖尿病组（2TDM组），每组各80例，同期选择健康体检的非糖尿病患者80例为对照组，抽取空腹血测定血管性血友病因子（vWF）、血小板a颗粒膜糖蛋白（CD62P）、溶酶体膜蛋白（CD63）与血管性血友病因子裂解酶（vWF—cp）的水平，分析其相关性。结果2TDM±CHD组患者CD62P、CD63、vWF水平分别为（11.3±6．4）％、（13．5±7．2）％、（166．9±18．7）％，显著高于2TDM组与对照组，差异有统计学意义（P〈0．05），而vWF—cp活性[（58．7±17．5）％]显著低于2TDM组与对照组（P〈0．05）；2TDM组患者CD62P、CD63、vWF水平分别为（7.3±3．5）％、（8.3±4．2）％、（142．3±20．8）％，显著高于对照组（P〈0．05），而vWF—cp活性[（65．4±18．1）％1显著低于对照组（P〈0．05），直线相关分析表明冠脉病变积分与vWF水平呈正相关（r=0．732，P〈0．05）。结论血浆vWF水平与2型糖尿病发生、发展、内皮损伤有关，且与2型糖尿病冠心病的发生存在一定关联，加强血浆vWF检测在糖尿病发病及冠心病发展的监测中具有一定的临床价值。Objective To explore and study the change of von Willebrand factor （vWF） levels to patients with type 2 dia-betes mellitus （2TDM） and its relationship with coronary heart disease （CHD）. Methods 160 cases of elderly patients with type 2 diabetes from January 2010 to January 2013 in Inner Mongolia People＇s Hospital were selected as the research object. According to the diagnostic criteria for type 2 diabetes, they were divided into the group of type 2 diabetes mellitus combined with coronary heart disease （2TDM＋CHD group） and the group of pure type 2 diabetes mellitus （2TDM group）, with 80 cases in each group. 80 cases of non-diabetic patients with physical examination at the same period were selected as the control group, the level of von Willebrand factor （vWF）, platelet granule membrane glyeoprotein a （CD62P）, lysosome membrane pro-tein （CD63） and yon Willebrand factor lyase （vWF-ep） were determined by extracting the fasting blood and their correlation were analyzed. Results The CD62P, CD63, vWF levels of patients in 2TDM＋CHD group were （11.3±6.4）%, （13.5±7.2）%, （166.9±18.7）% respectively, which were significantly higher than those in 2TDM group and control group （P 〈 0.05）, while vWF-cp activity was significantly lower than that in 2TDM group and control group （P 〈 0.05）; the CD62P, CD63, vWF level of pa-tients in 2TDM group were （7.3±3.5）%, （8.3±4.2）%, （142.3±20.8）% respectively, which were significantly higher thanthose in normal control group （P〈 0. 05）, while the vWF-cp activity [（65.4±18.1）%] was significantly lower than that in control group （P 〈 0.05）, the linear correlation analysis showed that coronary disease score and vWF levels were positive correlated （r = 0.732, P 〈 0.05）. Conclusion Plasma vWF level is related to the occurrence, development and endothelial injury of type 2 diabetes mellitus, and there is a certain correlation with the incidence of type 2 diabetes mellitus with coronary heart

关 键 词：2型糖尿病 血管性血友病因子 冠心病 

分 类 号：R587.1[医药卫生—内分泌]