心得宁口服液对小鼠耳壳微循环的影响  

Effect of Practolol Oral Liquid on Mice Auricle Microcirculation

作　　者：易伟国[1] 赵京生[1] 刘宏[1] 

机构地区：[1]中国人民解放军第152中心医院,河南平顶山467000

出　　处：《中医学报》2013年第11期1671-1672,共2页Acta Chinese Medicine

基　　金：河南省科学技术厅2009年科技发展计划项目(编号:092102310202)

摘　　要：目的：观察心得宁口服液对肾上腺素致小鼠微循环障碍模型细静脉、细动脉管径毛细血管开放数、微循环血流情况的影响。方法：取体质量18~21g小鼠50只,雌雄各半,随机分为5组。分别灌服大、中、小剂量心得宁口服液,芪苈强心胶囊混悬液,同体积生理盐水。用全自动图像分析仪观察各组小鼠耳廓细动脉（A）、细静脉（V）管径、血流速度及毛细血管开放数。结果：心得宁口服液组均可显著对抗肾上腺素所致小鼠耳壳细动脉、细静脉管径的收缩（P〈0.01）,可显著改善肾上腺素致小鼠耳壳微循环障碍模型微循环血流情况（P〈0.01）。结论：心得宁口服液可显著改善小鼠微循环障碍模型耳壳微循环的作用。Objective： To study the experience of Practolol oral liquid on capillary opening number and microcirculatory blood flow conditions of microcirculation disturbance in mouse model induced by epinephrine.Methods： 18-21 g mice,50,male and female in half,were randomly divided into 5 groups.Irrigation respectively take larg,medium and small dose result under Practolol oral liquid and Qiliqiangxin capsule suspension,with physiological saline volume.Use automatic image analyzer to observe mice auricle fine artery（A）,fine vein（V） diameter,blood flow velocity and the number of open capillary.Results： The Practolol oral liquid groups can be significantly against artery and vein diameter contraction induced by adrenaline（P 0.01） and significantly improve microcirculation blood flow conditions（P 0.01）.Conclusion： Practolol oral liquid can improve the auricle microcirculation in microcirculation disturbance in mouse model induced by epinephrine.

关 键 词：心得宁口服液 耳壳微循环 小鼠 肾上腺素 芪苈强心胶囊 

分 类 号：R285.5[医药卫生—中药学]